Effect of Helicobacter Pylori on the Availability of Vitamin E and C
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|ClinicalTrials.gov Identifier: NCT00303160|
Recruitment Status : Unknown
Verified August 2007 by University of Toronto.
Recruitment status was: Active, not recruiting
First Posted : March 15, 2006
Last Update Posted : August 14, 2007
|Condition or disease||Intervention/treatment||Phase|
|Heliobacter Pylori Infection||Drug: vitamin C & E supplements||Phase 4|
It has been postulated that dietary antioxidants may reduce cancer risk by modulating red-ox status, by preventing biological oxidation, and by inhibiting the formation of carcinogen. However, supplementation studies and prospective studies have yielded contradictory results. In the case of gastric cancer, H.pylori infection, which is known to be associated with a higher risk of the disease, results in an increased production of ROS & RNS. As a result serum levels of these free radicals increase, exerting a higher demand for dietary antioxidants to neutralize them.
The fact that the relation between serum levels of antioxidants and gastric cancer is more consistent than that of dietary intake levels and the disease suggests the possibility of the presence of an intrinsic factor that is altering the true relation between dietary antioxidants and the cancer. This intrinsic factor, this study argues, is the infection with H.pylori.
H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants that serve in quenching the free radicals, thus decreasing their serum levels and confounding their protective effect against gastric cancer. The purpose of this pilot study is to investigate the possibility that H.pylori infection alters the bioavailability of the dietary antioxidants: vitamin C, and vitamin E. This project will be done in preparation for an etiologic study of dietary antioxidants and gastric cancer.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||72 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Helicobacter Pylori on the Availability of Vitamin E and C|
|Study Start Date :||March 2006|
|Estimated Study Completion Date :||September 2007|
- plasma vitamin C levels
- plasma vitamin E levels
- TBARS levels
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00303160
|Toronto General Hospital|
|Toronto, Ontario, Canada|
|Principal Investigator:||Farah Naja, MSc.||Canada: Cancer Care Ontario|