Changes in Brain Activity (Functional MRI Study) Before and After Behavioral Therapy of Height Phobia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00302978
Recruitment Status : Completed
First Posted : March 15, 2006
Last Update Posted : December 15, 2011
Information provided by (Responsible Party):
New York State Psychiatric Institute

Brief Summary:
We are interested in investigating the functional brain abnormalities of height phobia. Subjects will be have a functional MRI scan before and after a course of treatment with behavioral therapy.

Condition or disease Intervention/treatment Phase
Height Phobia Fear of Heights Behavioral: Behavior therapy Not Applicable

Detailed Description:
The purpose of this study is to investigate the effects of in vivo exposure therapy on the functional brain activity of subjects with height phobia using a fear provocation paradigm. We expect differential activation of the fear circuitry in height phobics compared to non-phobic controls, and that successful behavioral therapy will normalize the heightened fear response in height phobia.

Study Type : Interventional  (Clinical Trial)
Enrollment : 40 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effects of in Vivo Exposure Therapy on the Neural Correlates of Height Phobia: a Functional Magnetic Resonance Imaging Study Using a Fear Provocation Paradigm.
Study Start Date : March 2006
Actual Study Completion Date : June 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Phobias

Primary Outcome Measures :
  1. CGI

Secondary Outcome Measures :
  1. acrophobia questionnaire

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Specific phobia of Heights

Exclusion Criteria:

  • History of medical problems

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00302978

Sponsors and Collaborators
New York State Psychiatric Institute
Principal Investigator: Yujuan Choy, M.D. New York State Psychiatric Institute, Columbia University

Responsible Party: New York State Psychiatric Institute Identifier: NCT00302978     History of Changes
Other Study ID Numbers: 5215
First Posted: March 15, 2006    Key Record Dates
Last Update Posted: December 15, 2011
Last Verified: April 2007

Keywords provided by New York State Psychiatric Institute:
Height phobia
fear of heights
specific phobia

Additional relevant MeSH terms:
Phobic Disorders
Anxiety Disorders
Mental Disorders