This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Changes in Brain Activity (Functional MRI Study) Before and After Behavioral Therapy of Height Phobia

This study has been completed.
Information provided by (Responsible Party):
New York State Psychiatric Institute Identifier:
First received: March 14, 2006
Last updated: December 14, 2011
Last verified: April 2007
We are interested in investigating the functional brain abnormalities of height phobia. Subjects will be have a functional MRI scan before and after a course of treatment with behavioral therapy.

Condition Intervention
Height Phobia Fear of Heights Behavioral: Behavior therapy

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Effects of in Vivo Exposure Therapy on the Neural Correlates of Height Phobia: a Functional Magnetic Resonance Imaging Study Using a Fear Provocation Paradigm.

Resource links provided by NLM:

Further study details as provided by New York State Psychiatric Institute:

Primary Outcome Measures:
  • CGI

Secondary Outcome Measures:
  • acrophobia questionnaire

Estimated Enrollment: 40
Study Start Date: March 2006
Study Completion Date: June 2006
Detailed Description:
The purpose of this study is to investigate the effects of in vivo exposure therapy on the functional brain activity of subjects with height phobia using a fear provocation paradigm. We expect differential activation of the fear circuitry in height phobics compared to non-phobic controls, and that successful behavioral therapy will normalize the heightened fear response in height phobia.

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Specific phobia of Heights

Exclusion Criteria:

  • History of medical problems
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00302978

Sponsors and Collaborators
New York State Psychiatric Institute
Principal Investigator: Yujuan Choy, M.D. New York State Psychiatric Institute, Columbia University
  More Information

Responsible Party: New York State Psychiatric Institute Identifier: NCT00302978     History of Changes
Other Study ID Numbers: 5215
Study First Received: March 14, 2006
Last Updated: December 14, 2011

Keywords provided by New York State Psychiatric Institute:
Height phobia
fear of heights
specific phobia

Additional relevant MeSH terms:
Phobic Disorders
Anxiety Disorders
Mental Disorders processed this record on June 23, 2017