In-Hospital Hyperglycemia: Effects of Treatment on Glycemic Control and Clinical Outcome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00302874
Recruitment Status : Completed
First Posted : March 15, 2006
Last Update Posted : March 26, 2007
Information provided by:
Hadassah Medical Organization

Brief Summary:

To improve glycemic control of inpatients admitted to the internal medicine wards, the researchers generated a protocol based on intensive insulin treatment for use in all inpatients with hyperglycemia.

The researchers hypothesize that intensive insulin treatment will improve the glycemic control and the outcome of hospitalized patients.

Study Information:

  • All patients with a history of diabetes admitted to the internal medicine ward were enrolled in the study.
  • At baseline, demographic and clinical information were obtained, including information necessary to determine the severity of the illness. Venous capillary blood glucose levels were checked 4 times a day by glucometer.
  • During the pre-intervention period, patients were treated according to the common practice in the hospital without any intervention. The study team collected the baseline data on the glycemic control and treatment of patients admitted with hyperglycemia.
  • During the intervention period, the study team visited the ward daily and guided the medical staff as to the use of the treatment protocol.
  • During the post-intervention period, the study team collected the data without active intervention in the implementation of the protocol.
  • Data was collected on the mode of treatment and glycemic control of all hyperglycemic patients throughout the study. The incidence of hypoglycemia, complications (myocardial infarction, stroke, infections), mortality, transfer to intensive care unit (ICU), length of hospitalization, and disposition at discharge were noted.

Condition or disease Intervention/treatment Phase
Diabetes Hyperglycemia Behavioral: Implementation of a protocol for treatment of hyperglycemia Not Applicable

Study Type : Interventional  (Clinical Trial)
Enrollment : 400 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: In-Hospital Hyperglycemia: Effects of Treatment on Glycemic Control and Clinical Outcome
Study Start Date : February 2003
Study Completion Date : October 2004

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Mean blood glucose during hospitalization

Secondary Outcome Measures :
  1. Hypoglycemic events
  2. Length of in-hospital stay
  3. Infections
  4. Complications (myocardial infarction, stroke)
  5. Disposition at discharge (home, nursing home)

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All patients admitted to the internal medicine ward with hyperglycemia

Exclusion Criteria:

  • Patients admitted due to hypoglycemia, hyperosmolar state, and ketoacidosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00302874

Hadassah Medical Organization
Jerusalem, Israel, 91120
Sponsors and Collaborators
Hadassah Medical Organization
Principal Investigator: Gil Leibowitz, MD Hadassah Medical Organization Identifier: NCT00302874     History of Changes
Other Study ID Numbers: gil362-HMO-CTIL
First Posted: March 15, 2006    Key Record Dates
Last Update Posted: March 26, 2007
Last Verified: October 2002

Keywords provided by Hadassah Medical Organization:
medicine ward

Additional relevant MeSH terms:
Glucose Metabolism Disorders
Metabolic Diseases