The Final Diagnosis and Treatment Result of Metastatic Cervical Carcinoma of Unknown Primary

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00302588
Recruitment Status : Unknown
Verified December 2005 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : March 14, 2006
Last Update Posted : March 14, 2006
Information provided by:
National Taiwan University Hospital

Brief Summary:
Investigate the final diagnosis and treatment result of metastatic cervical carcinoma of unknown primary

Condition or disease
Metastasis Cervical Lymph Nodes of Unknown Primary Carcinoma

Detailed Description:
Carcinoma of unknown primary (CUP) is defined as biopsy-proven metastasis of an epithelial malignancy in the absence of an identifiable primary site after complete history and physical examination, basic laboratory studies, chest X-ray and additional directed studies indicated by positive findings during the initial work-up. It is characterized by its slow local development and its high metastatic potential.1,2 Patients with CUP represent 4–10% of all new cancer patients.3,4 The presenting sites of metastasis identified pathologically, radiographically or by physical examination were found most frequently in the lymph nodes (37.1%), followed by the liver, bone, lung, pleura/pleural space, brain, peritoneum, adrenal and skin. Of the lymph nodes of metastasis, the supraclavicular cervical area is the leading site (31.3%), followed by the mediastinum, axilla, retroperitonium, and inguina.5 The incidence of metastatic cervical CUP (MCCUP) varies between 2% and 9% of all head and neck cancers.6-8 The level of cervical metastatic involvement may give some clue as to the likely primary site. A submandibular mass (level I) would most commonly be related to a primary in the oral cavity or skin. Level II nodes, including the jugulodigastric node, may point to a primary in the oral cavity, oropharynx, or supraglottic larynx. Tumours of the nasopharynx generally spread to level II or the posterior triangle, as well as retropharyngeal nodes. Middle and lower jugular nodes (levels III and IV) are more likely related to a laryngeal or hypopharyngeal cancer. Metastatic disease restricted to the supraclavicular region is often due to an infraclavicular primary site.9 The prognosis is different according to the involved lymph node level and possible primary site. Modern cancer management relies heavily on recognition of the primary tumor; thus the absence of a primary site poses major diagnostic and therapeutic problems. The patient benefits from identification of the initial tumor site because postoperative irradiation ports may be reduced and because surveillance for recurrence may be improved.10 In order to identify the likely primary site of MCCUP and compare the prognoses of known and unknown primary groups, we report the results according to the different levels of metastatic cervical lymph nodes.

Study Type : Observational
Enrollment : 100 participants
Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective
Study Start Date : January 2006
Study Completion Date : February 2006

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   20 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • cases of metastatic cervical carcinoma of unknown primary

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00302588

Contact: Ching-Ting Tan, MD, PhD 886-2-23123456 ext 5222

National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Ching-Ting Tan, MD, PhD    886-2-23123456 ext 5222   
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Ching-Ting Tan, MD, PhD National Taiwan University Hospital Identifier: NCT00302588     History of Changes
Other Study ID Numbers: 9461701257
First Posted: March 14, 2006    Key Record Dates
Last Update Posted: March 14, 2006
Last Verified: December 2005

Keywords provided by National Taiwan University Hospital:
metastatic carcinoma
cervical lymph nodes
unknown primary

Additional relevant MeSH terms:
Neoplasms, Unknown Primary
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasm Metastasis
Neoplastic Processes
Pathologic Processes