Therapeutic Effect of Immunoadsorption for Patients With Lipoprotein Glomerulopathy
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The purpose of this study is to assess the efficacy and safety of immunoadsorption in the treatment of lipoprotein glomerulopathy.
Condition or disease
Lipoprotein glomerulopathy is characterized by nephritic syndrome glomerular protein thrombi and lipid abnormalities, particularly with an elevated level of plasma apoprotein E (apoE).There are no efficiency way to treat lipoprotein glomerulopathy. We firstly successfully treat 2 patients by protein A immunoadsorption with remarkable decreased urine protein and reduction of lipoprotein thrombi on repeated renal biopsy.
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Ages Eligible for Study:
15 Years to 60 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
A new diagnosis of lipoprotein glomerulopathy proved by histology and serology
Age 15~60 years, sex free
Serum creatinine > 500 umol/l
Severe viral infection(HBV, HCV, CMV) within 3 months of first randomization or known HIV infection
Congenital or acquired immunodeficiency
Patients with severe infection or central nervous system symptoms
Immediately life-threatening organ manifestations (e.g. lung haemorrhage or massive gastro-intestinal bleeding, heart failure due to pericarditis or myocarditis, liver dysfunction measured on at least 2 separate occasion)