B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Prevention
|Official Title:||B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients|
- heart rate
- blood pressure
- enegy expenditure
- energy intake
- subjective appetite sensations
|Study Start Date:||January 2000|
|Estimated Study Completion Date:||December 2000|
Background: Long-term weight maintenance of a weight loss is often unsuccessful. Often a weight regain is observed in most studies that could indicate that most subjects are not able to change their eating habits. There is a need for simple and safe methods to prevent weight gain and re-gain i.e. by increasing thermogenesis and decrease spontaneous energy intake (EI). Studies have shown that nutritional and food-related non-nutritional factors influence the adjustment of EI and EE as the compounds can enhance the diet-induced thermogenesis (DIT) and suppress appetite.
Method: The present study was designed as a 4-way crossover, randomised, placebo controlled, dou-ble-blind study. Each treatment was separated by >3 d washout period. All treatments were administered as tablets containing either 500 mg green tea extract (whereof 125 mg cate-chins), 400 mg tyrosine, 50 mg anhydrous caffeine, or placebo.
on each test day body weight and composition was assessed. All participants underwent a 4.5-h assessment of energy expenditure by indirect calorimetry in a ventilated hood. Energy intake recorded of an ad libitum pasta salad brunch served after the last hood measurement
Subjects: Twelve healthy lean (20<BMI<25) weight stable non-smoking subjects between 18-40 years of age were tested 4 times each with a wash-out period of at least 3 days.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00302289
|Department of Human Nutrition, The Royal Veterinary and Agricultural University|
|Frederiksberg, Denmark, 1958|
|Principal Investigator:||Astrup Arne, Prof||Department of Human Nutrition, The Royal Veterinary and Agricultural University, Denmark|