B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00302289|
Recruitment Status : Completed
First Posted : March 14, 2006
Last Update Posted : March 14, 2006
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Drug: tyrosine, green tea, caffeine||Phase 1|
Background: Long-term weight maintenance of a weight loss is often unsuccessful. Often a weight regain is observed in most studies that could indicate that most subjects are not able to change their eating habits. There is a need for simple and safe methods to prevent weight gain and re-gain i.e. by increasing thermogenesis and decrease spontaneous energy intake (EI). Studies have shown that nutritional and food-related non-nutritional factors influence the adjustment of EI and EE as the compounds can enhance the diet-induced thermogenesis (DIT) and suppress appetite.
Method: The present study was designed as a 4-way crossover, randomised, placebo controlled, dou-ble-blind study. Each treatment was separated by >3 d washout period. All treatments were administered as tablets containing either 500 mg green tea extract (whereof 125 mg cate-chins), 400 mg tyrosine, 50 mg anhydrous caffeine, or placebo.
on each test day body weight and composition was assessed. All participants underwent a 4.5-h assessment of energy expenditure by indirect calorimetry in a ventilated hood. Energy intake recorded of an ad libitum pasta salad brunch served after the last hood measurement
Subjects: Twelve healthy lean (20<BMI<25) weight stable non-smoking subjects between 18-40 years of age were tested 4 times each with a wash-out period of at least 3 days.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||12 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients|
|Study Start Date :||January 2000|
|Study Completion Date :||December 2000|
- heart rate
- blood pressure
- enegy expenditure
- energy intake
- subjective appetite sensations
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00302289
|Department of Human Nutrition, The Royal Veterinary and Agricultural University|
|Frederiksberg, Denmark, 1958|
|Principal Investigator:||Astrup Arne, Prof||Department of Human Nutrition, The Royal Veterinary and Agricultural University, Denmark|