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Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

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ClinicalTrials.gov Identifier: NCT00300794
Recruitment Status : Completed
First Posted : March 9, 2006
Last Update Posted : November 14, 2006
Sponsor:
Information provided by:
Vilnius University

Brief Summary:
The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

Condition or disease Intervention/treatment Phase
Opiate Dependence Drug: Ketamine Phase 4

Study Type : Interventional  (Clinical Trial)
Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : February 2003
Study Completion Date : June 2006

Resource links provided by the National Library of Medicine

Drug Information available for: Ketamine





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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
  • Duration of substance abuse more than 1 year
  • No or minor co-morbidities;
  • Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion Criteria:

  • Current history of long acting opiate or poly-substance abuse;
  • Acute medical or surgical condition;
  • Pregnancy;
  • Breastfeeding.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00300794


Locations
Lithuania
Vilnius University Emergency Hospital
Vilnius, Lithuania
Sponsors and Collaborators
Vilnius University
Investigators
Study Director: Juozas Ivaskevicius, Prof. Vilnius University Clinic of Anaesthesiology and Intensive Care
Principal Investigator: Tomas Jovaisa, MD Vilnius University Clinic of Anaesthesiology and Intensive Care

Publications of Results:
ClinicalTrials.gov Identifier: NCT00300794     History of Changes
Other Study ID Numbers: PROT N1 V1_5
First Posted: March 9, 2006    Key Record Dates
Last Update Posted: November 14, 2006
Last Verified: November 2006

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Ketamine
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action