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Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00298454
Recruitment Status : Terminated (Number included has been reached)
First Posted : March 2, 2006
Last Update Posted : April 19, 2007
Information provided by:
Medical Centre Leeuwarden

Brief Summary:
Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria. Whether or not the administration of diuretics at that moment is appropriate is not known. The study randomises between furosemide or placebo when hemofiltration is stopped. Study endpoint is recovery of renal function.

Condition or disease Intervention/treatment Phase
Renal Failure Critically Ill Drug: Furosemide Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 72 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Forced Diuresis Vs Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients (Fodorefh)
Study Start Date : December 2005
Actual Study Completion Date : April 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Furosemide

Primary Outcome Measures :
  1. Creatinin clearance

Secondary Outcome Measures :
  1. length of stay in the intensive care and hospital
  2. intensive care and hospital mortality

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • cessation of hemofiltration
  • mechanical ventilation
  • written informed consent

Exclusion Criteria:

  • pre-existent renal failure
  • glomerulonephritis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00298454

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Dept of intensive care, Medical Centre Leeuwarden
Leeuwarden, Fr, Netherlands, 8901 BR
Sponsors and Collaborators
Medical Centre Leeuwarden
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Principal Investigator: Peter van der Voort, MD, PhD, MSc Dept of intensive care, Medical Centre Leeuwarden, PO Box 888,8901BR Leeuwarden, The Netherlands

Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00298454    
Other Study ID Numbers: 200601
First Posted: March 2, 2006    Key Record Dates
Last Update Posted: April 19, 2007
Last Verified: April 2007
Keywords provided by Medical Centre Leeuwarden:
renal failure
critically ill
Additional relevant MeSH terms:
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Renal Insufficiency
Critical Illness
Disease Attributes
Pathologic Processes
Kidney Diseases
Urologic Diseases
Natriuretic Agents
Physiological Effects of Drugs
Sodium Potassium Chloride Symporter Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action