Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients

This study has been terminated.
(Number included has been reached)
Information provided by:
Medical Centre Leeuwarden Identifier:
First received: March 1, 2006
Last updated: April 18, 2007
Last verified: April 2007
Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria. Whether or not the administration of diuretics at that moment is appropriate is not known. The study randomises between furosemide or placebo when hemofiltration is stopped. Study endpoint is recovery of renal function.

Condition Intervention Phase
Renal Failure
Critically Ill
Drug: Furosemide
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Forced Diuresis Vs Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients (Fodorefh)

Resource links provided by NLM:

Further study details as provided by Medical Centre Leeuwarden:

Primary Outcome Measures:
  • Creatinin clearance

Secondary Outcome Measures:
  • length of stay in the intensive care and hospital
  • intensive care and hospital mortality

Estimated Enrollment: 72
Study Start Date: December 2005
Study Completion Date: April 2007
  Show Detailed Description


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • cessation of hemofiltration
  • mechanical ventilation
  • written informed consent

Exclusion Criteria:

  • pre-existent renal failure
  • glomerulonephritis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00298454

Dept of intensive care, Medical Centre Leeuwarden
Leeuwarden, Fr, Netherlands, 8901 BR
Sponsors and Collaborators
Medical Centre Leeuwarden
Principal Investigator: Peter van der Voort, MD, PhD, MSc Dept of intensive care, Medical Centre Leeuwarden, PO Box 888,8901BR Leeuwarden, The Netherlands
  More Information

No publications provided by Medical Centre Leeuwarden

Additional publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00298454     History of Changes
Other Study ID Numbers: 200601
Study First Received: March 1, 2006
Last Updated: April 18, 2007
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Medical Centre Leeuwarden:
renal failure
critically ill

Additional relevant MeSH terms:
Critical Illness
Renal Insufficiency
Disease Attributes
Kidney Diseases
Pathologic Processes
Urologic Diseases
Cardiovascular Agents
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sodium Potassium Chloride Symporter Inhibitors
Therapeutic Uses processed this record on November 25, 2015