We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients

This study has been terminated.
(Number included has been reached)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00298454
First Posted: March 2, 2006
Last Update Posted: April 19, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Medical Centre Leeuwarden
  Purpose
Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria. Whether or not the administration of diuretics at that moment is appropriate is not known. The study randomises between furosemide or placebo when hemofiltration is stopped. Study endpoint is recovery of renal function.

Condition Intervention Phase
Renal Failure Critically Ill Drug: Furosemide Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Forced Diuresis Vs Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients (Fodorefh)

Resource links provided by NLM:


Further study details as provided by Medical Centre Leeuwarden:

Primary Outcome Measures:
  • Creatinin clearance

Secondary Outcome Measures:
  • length of stay in the intensive care and hospital
  • intensive care and hospital mortality

Estimated Enrollment: 72
Study Start Date: December 2005
Study Completion Date: April 2007
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • cessation of hemofiltration
  • mechanical ventilation
  • written informed consent

Exclusion Criteria:

  • pre-existent renal failure
  • glomerulonephritis
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00298454


Locations
Netherlands
Dept of intensive care, Medical Centre Leeuwarden
Leeuwarden, Fr, Netherlands, 8901 BR
Sponsors and Collaborators
Medical Centre Leeuwarden
Investigators
Principal Investigator: Peter van der Voort, MD, PhD, MSc Dept of intensive care, Medical Centre Leeuwarden, PO Box 888,8901BR Leeuwarden, The Netherlands
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00298454     History of Changes
Other Study ID Numbers: 200601
First Submitted: March 1, 2006
First Posted: March 2, 2006
Last Update Posted: April 19, 2007
Last Verified: April 2007

Keywords provided by Medical Centre Leeuwarden:
renal failure
oliguric
critically ill
furosemide

Additional relevant MeSH terms:
Critical Illness
Renal Insufficiency
Disease Attributes
Pathologic Processes
Kidney Diseases
Urologic Diseases
Furosemide
Diuretics
Natriuretic Agents
Physiological Effects of Drugs
Sodium Potassium Chloride Symporter Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action