Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease
Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood. We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A & D TM2425). We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.
Device: Ambulatory blood pressure monitoring
|Study Design:||Observational Model: Natural History
Time Perspective: Longitudinal
|Official Title:||Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease|
|Study Start Date:||February 2004|
|Study Completion Date:||December 2006|
The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance. Patients with chronic renal disease participate in the study. Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week. The mean waking and sleeping time systolic and diastolic blood pressure are calculated. LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00298129
|Yokohama City University Center Hospital|
|Yokohama, Japan, 232-0024|
|Principal Investigator:||Gen Yasuda, MD||Yokohama City University Center Hospital|