Molecular Associations With Reproductive Failure
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|ClinicalTrials.gov Identifier: NCT00298116|
Recruitment Status : Completed
First Posted : March 1, 2006
Last Update Posted : December 8, 2014
|Condition or disease|
|Spontaneous Abortions Infertility|
The overall hypothesis to be tested is: women with the molecular phenotype of highly skewed X chromosome inactivation are at increased risk of spontaneous abortion.
We will investigate this hypothesis through two complimentary aims. In the Background and Significance section, we first present data on a 53-member pedigree segregating an X-linked recessive lethal defect that results in skewed X inactivation in the carrier females via secondary selection against those cells with the defective X chromosome active. We have characterized this deletion to be a 500 kb (approximate) deletion in distal Xq28. Moreover, the carrier females show a statistically significant increase in the frequency of spontaneous abortion as compared to non-deletion carrying relatives. Secondly, in the Preliminary Studies section, we present data from a population based case-control study wherein highly skewed X chromosome inactivation is significantly correlated with idiopathic recurrent spontaneous abortion. This protocol attempts to elucidate the mechanism underlying this association.
The first specific aim is to determine if women with highly skewed X chromosome inactivation are at risk of pregnancy loss. This will be accomplished through a prospective protocol, analyzing X chromosome inactivation patterns in pregnant women and investigating a possible association between X chromosome inactivation and pregnancy outcome. The second aim will study the nature of pregnancy loss in women with skewed X chromosome inactivation. This aim will correlate maternal X inactivation patterns with abortus karyotype.
|Study Type :||Observational|
|Actual Enrollment :||475 participants|
|Observational Model:||Case Control|
|Official Title:||Molecular Associations With Reproductive Failure|
|Study Start Date :||September 2000|
|Actual Primary Completion Date :||January 2008|
|Actual Study Completion Date :||January 2008|
- Skewed X-Inactivation is not associated with Reproductive Failure [ Time Frame: 5 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00298116
|United States, Pennsylvania|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||W. Allen Hogge, MD||University of Pittsburgh and Magee-Womens Hospital|