Risperidone Augmentation for Treatment-Resistant Aggression in ADHD
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Ages Eligible for Study:
7 Years to 12 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Boys and girls ages 7 to 12 years, inclusive
Meets DSM-IV diagnosis of ADHD
Treatment with a stimulant medication during the last three weeks
Failure to respond to stimulant medication as documented by:
Three acts of aggression in the past week, two of which must be acts of physical aggression against other people, objects, or self
Aggression Questionnaire (AQ) Predatory-Affective index score of 0 or below. This indicates primarily an affective or impulsive subtype of aggression
Minimum CGI scale rating of 4 (moderately ill)
IQ > 75 -
Major medical problems such as cardiac, renal, thyroid diseases, and seizure disorder
History of alcohol or substance abuse within the last 4 weeks
Previous adequate treatment with risperidone (2 mg/day for at least 4 weeks)