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Effect of Sildenafil on Endothelial Function

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ClinicalTrials.gov Identifier: NCT00297544
Recruitment Status : Unknown
Verified November 2005 by Rambam Health Care Campus.
Recruitment status was:  Recruiting
First Posted : February 28, 2006
Last Update Posted : February 28, 2006
Sponsor:
Collaborator:
Pfizer
Information provided by:
Rambam Health Care Campus

Brief Summary:
We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Condition or disease Intervention/treatment Phase
Impotence Drug: Viagra Not Applicable

Detailed Description:
We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Study Type : Interventional  (Clinical Trial)
Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Educational/Counseling/Training
Official Title: Effect of Sildenafil on Endothelial Function
Study Start Date : October 2005

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Improvement of endothelial function following Viagra treatment, according to platismographia.


Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • age 40-70
  • impotence
  • with and without hypertension, Hypercholesteremia or DM

Exclusion Criteria:

  • CHF: NYHA > II
  • Stable angina: CCS > II
  • Nitrate treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00297544


Contacts
Contact: Giris Jacob, Prof., MD, DSc 972-4-854-2467 g_jacob@rambam.health.gov.il
Contact: Yuram Vardi, Prof. , MD 972-4-854-2819 y_vardi@rambam.health.gov.il

Locations
Israel
Rambam Medical Center, Recanati Autonomic Dysfunction CTR Recruiting
Haifa, Israel, 31096
Contact: Giris Jacob, MD, DSc    972-4-854-2594    g_Jacob@rambam.health.gov.il   
Principal Investigator: Yuram Vardi, MD         
Sponsors and Collaborators
Rambam Health Care Campus
Pfizer
Investigators
Principal Investigator: Giris Jacob, Prof, MD, DSc Rambam Health Care Campus

Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00297544     History of Changes
Other Study ID Numbers: 1777-CTIL
First Posted: February 28, 2006    Key Record Dates
Last Update Posted: February 28, 2006
Last Verified: November 2005

Keywords provided by Rambam Health Care Campus:
impotence
endothelial function
autonomic nervous system

Additional relevant MeSH terms:
Erectile Dysfunction
Sexual Dysfunction, Physiological
Genital Diseases, Male
Sexual Dysfunctions, Psychological
Mental Disorders
Sildenafil Citrate
Vasodilator Agents
Phosphodiesterase 5 Inhibitors
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Urological Agents