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Serotonin, Impulsivity, and Cocaine Dependence Treatment

This study has been completed.
Information provided by:
National Institute on Drug Abuse (NIDA) Identifier:
First received: February 27, 2006
Last updated: NA
Last verified: February 2006
History: No changes posted
The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.

Condition Intervention Phase
Cocaine Dependence
Drug: citalopram
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Serotonin, Impulsivity, and Cocaine Dependence Treatment

Resource links provided by NLM:

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:
  • The presence of cocaine metabolites in urine weekly.

Secondary Outcome Measures:
  • Retention rate and cocaine cravings weekly.

Estimated Enrollment: 120
Study Start Date: April 2001
Estimated Study Completion Date: November 2004
Detailed Description:
Cocaine dependence continues to be a significant public health problem, for which there is no FDA approved pharmacotherapy. This study is a 12-week, double blind, placebo controlled trial of citalopram for cocaine dependence. The primary outcome measure is benzoylecgonine positive urines. Secondary measures of side effects and craving are also examined.

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • male and female subjects age 18 to 50 who currently meet DSM-IV criteria for cocaine dependence.
  • female subjects: a negative pregnancy test

Exclusion Criteria:

  • current or past DSM-IV Axis I disorder other than substance abuse/dependence
  • any serious non-psychiatric medical illness requiring ongoing medical treatment
  • substance dependence other than cocaine within the last 3 months
  • negative urine drug screen for cocaine at time of testing
  • for female subjects: a positive pregnancy test
  Contacts and Locations
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Please refer to this study by its identifier: NCT00297505

United States, Texas
University of Texas – Houston Health Science Center
Houston, Texas, United States, 77030
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
Principal Investigator: Frederick G Moeller, M.D. The University of Texas Health Science Center, Houston
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00297505     History of Changes
Other Study ID Numbers: R01DA008425 
Study First Received: February 27, 2006
Last Updated: February 27, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute on Drug Abuse (NIDA):
Cocaine; citalopram; impulsivity; serotonin

Additional relevant MeSH terms:
Cocaine-Related Disorders
Impulsive Behavior
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents
Serotonin Receptor Agonists
Serotonin Agents
Serotonin Uptake Inhibitors
Antidepressive Agents, Second-Generation
Antidepressive Agents
Psychotropic Drugs
Antiparkinson Agents
Anti-Dyskinesia Agents processed this record on October 21, 2016