Serotonin, Impulsivity, and Cocaine Dependence Treatment
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.
Condition or disease
Cocaine dependence continues to be a significant public health problem, for which there is no FDA approved pharmacotherapy. This study is a 12-week, double blind, placebo controlled trial of citalopram for cocaine dependence. The primary outcome measure is benzoylecgonine positive urines. Secondary measures of side effects and craving are also examined.
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Ages Eligible for Study:
18 Years to 50 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
male and female subjects age 18 to 50 who currently meet DSM-IV criteria for cocaine dependence.
female subjects: a negative pregnancy test
current or past DSM-IV Axis I disorder other than substance abuse/dependence
any serious non-psychiatric medical illness requiring ongoing medical treatment
substance dependence other than cocaine within the last 3 months
negative urine drug screen for cocaine at time of testing