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Improved Preoperative Selection of Cold Thyroid Nodules

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2007 by Herlev Hospital.
Recruitment status was:  Enrolling by invitation
Information provided by:
Herlev Hospital Identifier:
First received: February 27, 2006
Last updated: February 24, 2010
Last verified: October 2007
Molecular gene profiling of fine-needle aspiration samples in addition to fine-needle aspiration cytology can improve the selection of patients with benign versus malignant thyroid nodules with improved sensitivity.

Condition Intervention Phase
Thyroid Nodules Other: No intervention. Applying gene profiling on needle aspirates Phase 3

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Preoperative Selection of Solitary Solid Cold Thyroid Nodules - A Prospective Study on the Value of Sonography, Cytology, Immunostaining and Molecular Profiling

Resource links provided by NLM:

Further study details as provided by Herlev Hospital:

Estimated Enrollment: 100
Study Start Date: December 2008
Estimated Study Completion Date: March 2011
Intervention Details:
    Other: No intervention. Applying gene profiling on needle aspirates
    Other Name: Genetics - molecular profiling of tissue samples

Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Tertiary referral center (Endocrine outpatient - University Hosiptal - clinic). Patients referred with a solitary thyroid nodule

Inclusion Criteria:

  • Solitary thyroid nodules that appear solid on ultrasound and cold on a scintiscan

Exclusion Criteria:

  • Pregnancy and lactation
  • Age below 20 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT00297297

Outpatient clinic of The Department of Endocrinology, Herlev University Hospital
Copenhagen, Denmark, 2730
Sponsors and Collaborators
Herlev Hospital
Principal Investigator: Finn N Bennedbaek, MD, PhD Department of Endocrinology and Metabolism, Herlev University Hospital, DK-2730 Herlev, Denmark
  More Information

Responsible Party: Finn N Bennedbaek, Md, PhD (principal investigator), Herlev University Hospital Identifier: NCT00297297     History of Changes
Other Study ID Numbers: HH-FB-10
Study First Received: February 27, 2006
Last Updated: February 24, 2010

Keywords provided by Herlev Hospital:
Solitary solid and scintigraphically cold thyroid nodules

Additional relevant MeSH terms:
Thyroid Diseases
Thyroid Nodule
Thyroid Neoplasms
Endocrine System Diseases
Endocrine Gland Neoplasms
Neoplasms by Site
Head and Neck Neoplasms processed this record on September 19, 2017