Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass
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|ClinicalTrials.gov Identifier: NCT00297245|
Recruitment Status : Unknown
Verified January 2006 by Huazhong University of Science and Technology.
Recruitment status was: Recruiting
First Posted : February 28, 2006
Last Update Posted : February 28, 2006
|Condition or disease||Intervention/treatment||Phase|
|Cognitive Decline||Drug: cognitive function||Phase 4|
Cardiac surgery with cardiopulmonary bypass (CPB) is one of the most frequently performed operations. Neurobehavioral disorders, including neuropsychiatric and neuropsychological deficits, are a very frequently reported sequela of valve replacement or coronary artery bypass grafting (CABG) surgery. CPB is associated with significant cerebral morbidity. The incidence of cognitive decline related to CPB ranges from 20% to 80%, which may affect length of hospital stay, quality of life, the rehabilitation process, and work performance. Neurocognitive decline can present days to weeks after surgery and may remain a permanent disorder. Many pharmacologic strategies have been proposed or investigated for preventing post-CPB cognitive decline, but to our knowledge, none of these drugs has been systematically evaluated for efficacy in preventing post-CPB cognitive decline.
The causative parameters of cognitive dysfunction associated with CPB include cerebral ischemia secondary to either microemboli or hypoperfusion, intraoperative cerebrovascular risk factors such as the duration of CPB, inflammatory response, cerebral glutamine release, free radicals, and NO release.
Gastrodia elata, a famous Chinese medical herb, has effects on preventing ischemic brain injury, neuronal cell damage or apoptosis, suppressing inflammatory response, inhibiting glutamine receptors and nNOS, and scavenging free radicals. Gastrodin (4-[hydroxymethyl]phenyl-β-D-glucopyranoside), the primary active constituent of gastrodia elata, has been widely used for the treatment of paralysis, hemiplegia, headache, vertigo, and Alzheimer's disease. Based on its pharmacological effects, we postulated that gastrodin would attenuate the causative parameters of cognitive dysfunction related to CPB and would be an effective drug to prevent the decline as a result.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||200 participants|
|Intervention Model:||Parallel Assignment|
|Study Start Date :||February 2006|
|Study Completion Date :||May 2006|
- Gastrodin markedly prevents cognitive decline related to cardiopulmonary bypass
- neuropsychological tests
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00297245
|Contact: Shihai Zhang, M.D.,Ph.D.||firstname.lastname@example.org|
|Contact: Shihai Zhang, M.D., Ph.D.||email@example.com|
|Department of Anesthesiology, Union Hospital||Recruiting|
|Wuhan, Hubei, China, 430022|
|Contact: Shihai Zhang, M.D., Ph.D. 862-785-726-834 firstname.lastname@example.org|
|Principal Investigator: Shihai Zhang, M.D., Ph.D.|
|Principal Investigator:||Shihai Zhang||Department of Anesthesiology, Union Hosiptal, Tongji Medical College, Huazhong University of Science and Technology|
|Principal Investigator:||Shihai Zhang, M.D., Ph.D.||Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology|