A Study to Assess the Safety and Efficacy of an Investigational Drug (MK-686) in Patients With Osteoarthritis (0686-006)
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Ages Eligible for Study:
40 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with a clinical and radiographic diagnosis of osteoarthritis of the hip or knee,either prior NSAID or Acetaminophen users within the ARA functional class I,II or III and with no clinically significant diseases
Patients required to demonstrate a flare of the signs and symptoms of OA following withdrawal of NSAID treatment
Prior acetaminophen users also required to demonstrate greater than a defined minimum level of signs and symptoms of OA
females must be either post-menopausal or surgically sterilized
No history of concurrent arthritic disease
No history of neoplastic disease within a specified duration