CYA Versus MMF for Treatment of Moderate-Severe Psoriasis.
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ClinicalTrials.gov Identifier: NCT00295425
Recruitment Status : Unknown
Verified October 2006 by University Hospital Muenster. Recruitment status was: Active, not recruiting
Psoriasis is an immuno-mediated skin disorder, which affects about 2-3% of the population worldwide. For moderate-severe forms of psoriasis systemic immunosuppression is the treatment of choice. This clinical trial was initiated to compare the safety and effectiveness of mycophenolate mofetil and cyclosporine A for the treatment of psoriasis. Patients are randomized to receive either 2.5 mg/kg BW cyclosporine A or 1 g bid mycophenolate mofetil. If after six weeks no decrease in the PASI score occures cyclosporine A doses are increased to 5 mg/kg BW for additional six weeks. In the other arm mycophenolate mofetil is increased to 1 g tid for additional six weeks.
Condition or disease
Drug: Cyclosporine A versus mycophenolate mofetil for psoriasis
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
moderate-to-severe psoriasis (PASI Score equal and greated 10)
written informed consent
for female patients effective birth control
previous treatment with cyclosporine A or mycophenolate mofetil