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The Impact of Quetiapine on the Drug Abuse Patterns of Addicted Schizophrenic Patients

This study has been completed.
Information provided by:
Université de Montréal Identifier:
First received: February 21, 2006
Last updated: NA
Last verified: September 2005
History: No changes posted
The lifetime of substance use disorders in schizophrenia is close to 50%. Substance abuse in schizophrenia is associated with negative consequences. Unfortunately, there no clear guidelines for the pharmacological treatment of this dual diagnosis population. Preliminary results suggest that second-generation antipsychotic drugs (mainly clozapine) may relieve drug cravings in schizophrenia. We performed a 12-week pilot study to evaluate the impact of quetiapine, a second-generation antipsychotic, on substance abuse parameters, psychiatric symptoms and side effects in patients schizophrenia and comorbid substance use disorders. Our expectation was a 20 % decrease in drug cravings from baseline to end-point.

Condition Intervention Phase
Schizophrenia Substance Use Disorders Drug: quetiapine (drug) Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: The Impact of Quetiapine on the Drug Abuse Patterns of Addicted Schizophrenic Patients

Resource links provided by NLM:

Further study details as provided by Université de Montréal:


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Patients with as schizophrenia spectrum disorder
  • Patients with a comorbid substance use disorder

Exclusion Criteria:

  • Patients already on quetiapine or clozapine
  • Patients hospitalized or acutely ill
  • Total score lower than 65 on the PANSS
  • Pregnancy
  • Female subjects of childbearing potential without adequate contraception
  • Abnormal liver function (hepatic enzymes more than 3 times the upper normal limits)
  • Any clinically meaningful unstable renal, hepatic, cardiovascular, respiratory, cerebrovascular disease or other serious, progressive physical disease.
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Please refer to this study by its identifier: NCT00295412

Canada, Quebec
Centre de recherche Fernand-Seguin
Montreal, Quebec, Canada, H1N 3V2
Sponsors and Collaborators
Université de Montréal
Principal Investigator: Emmanuel Stip, Md, MSc, CSPQ Centre de recherche Fernand-Seguin, Hôpital Louis-H Lafontaine, Departement of Psychiatry, Faculty of medicine, University of Montreal
  More Information Identifier: NCT00295412     History of Changes
Other Study ID Numbers: 5077-99904
Study First Received: February 21, 2006
Last Updated: February 21, 2006

Additional relevant MeSH terms:
Substance-Related Disorders
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Chemically-Induced Disorders
Quetiapine Fumarate
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Psychotropic Drugs processed this record on August 22, 2017