X-Chromosome Inactivation Status and Premature Ovarian Failure
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|ClinicalTrials.gov Identifier: NCT00295087|
Recruitment Status : Completed
First Posted : February 22, 2006
Last Update Posted : December 8, 2014
|Condition or disease|
|Premature Ovarian Failure|
Premature ovarian failure (POF) affects approximately 1% of women. For most women a cause is not found, but structural abnormalities of the X-chromosome commonly lead to POF, suggesting genes on the X-chromosome are necessary for normal ovarian function. It is known that certain gene mutations on the X-chromosome can lead to changes in the normal random pattern of X-chromosome inactivation in females.
We propose to study X-inactivation patterns in a cohort of women with idiopathic POF, and compare their pattern to a mean age-matched cohort of women with normal menstrual function.
We hypothesize that some women with POF will show skewed X-inactivation, suggesting a mutation on the X-chromosome as the etiology of their POF.
|Study Type :||Observational|
|Actual Enrollment :||13 participants|
|Official Title:||X-Chromosome Inactivation Status and Premature Ovarian Failure|
|Study Start Date :||November 2005|
|Actual Primary Completion Date :||October 2009|
|Actual Study Completion Date :||October 2009|
- Skewed X-Inactivation appears increased in women with Premature Ovarian Failure [ Time Frame: 4 years ]
Biospecimen Retention: Samples With DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00295087
|United States, Pennsylvania|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||W. Allen Hogge, MD||University of Pittsburgh and Magee-Womens Hospital|