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Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2006 by Lawson Health Research Institute.
Recruitment status was:  Recruiting
Information provided by:
Lawson Health Research Institute Identifier:
First received: February 17, 2006
Last updated: NA
Last verified: February 2006
History: No changes posted
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Condition Intervention
Vasopressor Agents
Endarterectomy, Carotid
Echocardiography, Transesophageal
Drug: Comparison of Effects of Phenylephrine and Norepinephrine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Official Title: Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia

Resource links provided by NLM:

Further study details as provided by Lawson Health Research Institute:

Primary Outcome Measures:
  • Myocardial ischemia measures by transesophageal echocardiography and ST segment analyses

Secondary Outcome Measures:
  • Myocardial ischemia measures by cardiac troponin I

Estimated Enrollment: 86
Study Start Date: February 2006
Estimated Study Completion Date: February 2006

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Elective carotid endarterectomy under general anesthesia
  • > 18 years old
  • Written informed consent

Exclusion Criteria:

  • Contraindication to general anesthesia
  • Contraindication to transesophageal anesthesia
  • esophageal disease
  • esophageal stricture
  • history of esophageal or gastric bleeding
  • esophageal anatomic abnormality
  • past esophageal or gastric surgery
  • severe dysphagia
  Contacts and Locations
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Please refer to this study by its identifier: NCT00294606

Contact: Rosemary A Craen, MD, FRCPC (519) 663-3022
Contact: Hélène G Pellerin, MD, FRCPC (519) 663-3022

Canada, Ontario
University Hospital, LHSC Recruiting
London, Ontario, Canada, N6A 5A5
Contact: Rosemary A Craen, MD, FRCPC    (519) 663-3022   
Principal Investigator: Rosemary A Craen, MD, FRCPC         
Sponsors and Collaborators
Lawson Health Research Institute
Principal Investigator: Rosemary A Craen, MD, FRCPC Associate Professor University of Western Ontario
  More Information Identifier: NCT00294606     History of Changes
Other Study ID Numbers: R-05-941
Study First Received: February 17, 2006
Last Updated: February 17, 2006

Keywords provided by Lawson Health Research Institute:
vasopressor agents
carotid endarterectomy
cardiac function
transesophageal echocardiography
wall motion abnormalities

Additional relevant MeSH terms:
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Autonomic Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Cardiotonic Agents
Nasal Decongestants
Respiratory System Agents
Adrenergic alpha-1 Receptor Agonists
Protective Agents processed this record on May 24, 2017