Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma
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ClinicalTrials.gov Identifier: NCT00294177
Verified February 2006 by National Taiwan University Hospital. Recruitment status was: Not yet recruiting
Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. The conformational change of tumor markers during antineoplastic chemotherapy for cancer and its clinical meaning has only been rarely studied. In this study, we will try to understand the conformational change of the tumor marker (hCG) during chemotherapy.
Condition or disease
Device: atomic force microscopyDevice: dual polarisation interferometry
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Ages Eligible for Study:
Child, Adult, Senior
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Clinical diagnosis of trophoblastic neoplasms
Willing to be collected for the urine and 2 ml blood samples
Unwilling to be collected for the collect urine or 2ml blood sample