Working… Menu

Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00294177
Recruitment Status : Unknown
Verified February 2006 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
First Posted : February 20, 2006
Last Update Posted : February 20, 2006
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital

Brief Summary:
Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. The conformational change of tumor markers during antineoplastic chemotherapy for cancer and its clinical meaning has only been rarely studied. In this study, we will try to understand the conformational change of the tumor marker (hCG) during chemotherapy.

Condition or disease Intervention/treatment
Trophoblastic Neoplasms Choriocarcinoma Device: atomic force microscopy Device: dual polarisation interferometry

  Show Detailed Description

Layout table for study information
Study Type : Observational
Enrollment : 30 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Persistent Gestational Trophoblastic Tumors Using Atomic Force Microscopy and Dual Polarisation Interferometry
Study Start Date : August 2006
Study Completion Date : July 2008

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of trophoblastic neoplasms
  • Willing to be collected for the urine and 2 ml blood samples

Exclusion Criteria:

  • Unwilling to be collected for the collect urine or 2ml blood sample

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00294177

Layout table for location contacts
Contact: Ruey-Jien Chen, MD, PhD 886-2-23123456 ext 5158

Layout table for location information
National Taiwan University Hospital Department of Obstetrics and Gynecology Not yet recruiting
Taipei, Taiwan, 100
Contact: Ruey-Jien Chen, MD, PhD    886-2-2312-3456 ext 5158   
Principal Investigator: Ruey-Jien Chen, MD, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
Layout table for investigator information
Principal Investigator: Ruey-Jien Chen Department or Obstetrics and Gynecology, National Taiwan university Hospital

Additional Information:
Layout table for additonal information Identifier: NCT00294177     History of Changes
Other Study ID Numbers: 9561702010
Taiwan NSC 94WFA0101857
First Posted: February 20, 2006    Key Record Dates
Last Update Posted: February 20, 2006
Last Verified: February 2006
Keywords provided by National Taiwan University Hospital:
Trophoblastic Neoplasms
Chorionic Gonadotropin
Molecular Conformation
Additional relevant MeSH terms:
Layout table for MeSH terms
Trophoblastic Neoplasms
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Pregnancy Complications, Neoplastic
Pregnancy Complications
Chorionic Gonadotropin
Reproductive Control Agents
Physiological Effects of Drugs