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Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2006 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00294177
First Posted: February 20, 2006
Last Update Posted: February 20, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Science Council, Taiwan
Information provided by:
National Taiwan University Hospital
  Purpose
Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. The conformational change of tumor markers during antineoplastic chemotherapy for cancer and its clinical meaning has only been rarely studied. In this study, we will try to understand the conformational change of the tumor marker (hCG) during chemotherapy.

Condition Intervention Phase
Trophoblastic Neoplasms Choriocarcinoma Device: atomic force microscopy Device: dual polarisation interferometry Phase 4

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Persistent Gestational Trophoblastic Tumors Using Atomic Force Microscopy and Dual Polarisation Interferometry

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 30
Study Start Date: August 2006
Estimated Study Completion Date: July 2008
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of trophoblastic neoplasms
  • Willing to be collected for the urine and 2 ml blood samples

Exclusion Criteria:

  • Unwilling to be collected for the collect urine or 2ml blood sample
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00294177


Contacts
Contact: Ruey-Jien Chen, MD, PhD 886-2-23123456 ext 5158 rjchen@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Department of Obstetrics and Gynecology Not yet recruiting
Taipei, Taiwan, 100
Contact: Ruey-Jien Chen, MD, PhD    886-2-2312-3456 ext 5158    rjchen@ha.c.ntu.edu.tw   
Principal Investigator: Ruey-Jien Chen, MD, PhD         
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
Investigators
Principal Investigator: Ruey-Jien Chen Department or Obstetrics and Gynecology, National Taiwan university Hospital
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT00294177     History of Changes
Other Study ID Numbers: 9561702010
Taiwan NSC 94WFA0101857
First Submitted: February 17, 2006
First Posted: February 20, 2006
Last Update Posted: February 20, 2006
Last Verified: February 2006

Keywords provided by National Taiwan University Hospital:
Trophoblastic Neoplasms
Chorionic Gonadotropin
Molecular Conformation

Additional relevant MeSH terms:
Choriocarcinoma
Trophoblastic Neoplasms
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Pregnancy Complications, Neoplastic
Pregnancy Complications
Chorionic Gonadotropin
Reproductive Control Agents
Physiological Effects of Drugs