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Alberta Hip Improvement Project

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Alberta Bone and Joint Health Institute Identifier:
First received: February 16, 2006
Last updated: July 18, 2016
Last verified: July 2016
A study to determine the effectiveness and safety of the use of metal-on-metal hip resurfacing (for example the birmingham hip) when compared to conventional total hip replacement.

Condition Phase
Arthroplasty, Replacement, Hip
Phase 4

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Provincial Initiative to Examine the Efficacy, Cost-effectiveness and Long-term Safety of Alternative Hip Bearing Surfaces Versus Conventional Therapy for Degenerative Joint Disease of the Hip

Resource links provided by NLM:

Further study details as provided by Alberta Bone and Joint Health Institute:

Biospecimen Retention:   Samples Without DNA
Blood samples retained for cobalt and chromium metal ion level analysis on select cohort.

Estimated Enrollment: 1000
Study Start Date: June 2004
Estimated Study Completion Date: September 2020
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Standard hip replacement subjects (polyethylene)
Alternative Bearing
Subjects with ceramic on ceramic total hip replacement or metal on metal hip resurfacing.

Detailed Description:
This study is designed to provide orthopedic surgeons and decision makers with evidence-based health measures for patients that are treated by orthopedic surgeons for degenerative joint disease of the hip in Alberta. This study is provincial initiative to determine whether new alternative hip bearing surfaces improve patient outcomes and/or decrease health resource utilization in patients with degenerative joint disease of the hip in Alberta. The primary objective is to compare time to revision for patients receiving alternative hip bearing surfaces to patients receiving conventional total hip replacements. Secondary objectives are to evaluate long-term safety; to evaluate costs; to determine if alternative hip bearing surfaces improve patient function; to develop evidence base guidelines for the implementation of alternative hip bearing surfaces in Alberta; do develop a modal to assess other technologies and health advances; to develop an Alberta HIP registry

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Males between the ages of 18-65 and females between the ages of 18-55

Inclusion Criteria:

  • documentation of DJD of hip
  • patient at least 18 years
  • patient able to provide written consent
  • Male under 65 years, female under 56 years
  • Orthopedic surgeon has received appropriate training to implant an alternative device

Exclusion Criteria:

  • renal failure (MOM only)
  • child bearing potential (MOM only)
  • inappropriate femoral anatomy, including evidence of osteoporosis
  • inflammatory arthritis (MOM)
  • Unwilling to consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00293774

Canada, Alberta
Alberta Bone and Joint Health Institute
Calgary, Alberta, Canada, T2N 2X6
Sponsors and Collaborators
Alberta Bone and Joint Health Institute
Principal Investigator: James MacKenzie, M.D. University of Calgary
Principal Investigator: Greg O'Connor, MD University of Alberta
  More Information

Responsible Party: Alberta Bone and Joint Health Institute Identifier: NCT00293774     History of Changes
Other Study ID Numbers: ABHIP-00001
Study First Received: February 16, 2006
Last Updated: July 18, 2016

Keywords provided by Alberta Bone and Joint Health Institute:
Conventional therapy
Hip Arthroplasty processed this record on May 25, 2017