Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00292136
Recruitment Status : Completed
First Posted : February 15, 2006
Last Update Posted : April 5, 2018
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:


  • The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence. Research has shown that constant reporting through personal data-collection devices, such as electronic diaries, can help prevent relapse and reinforce abstinence. This constant reporting is known as Ecological Momentary Assessment (EMA).
  • The researchers here at NIDA have already completed two major arms of the study, focusing on patterns of craving and drug use during methadone maintenance, and on whether electronic diaries could help remind outpatients to complete treatment tasks. An ongoing arm of the study is examining connections among drug craving/use, stress, and geographical location.


- To investigate the role of stress associated with geographical location in drug craving and use.


- Individuals between 18 and 65 years of age or older who are dependent on opioids (cocaine and/or heroin).


  • The study will last 28 weeks. After the initial screening, participants will receive daily methadone and weekly drug counseling sessions that will continue throughout the study.
  • After 3 weeks of methadone treatment, participants will have 15 weeks of EMA in which they will record both event-triggered cravings and daily responses (3 per day). EMA will consist of event-triggered recordings (initiated by participants whenever they use heroin or cocaine, or whenever they feel an urge to do so) and random-signal-triggered recordings (3 per day). During EMA, participants will begin a voucher-based program to encourage abstinence from heroin and cocaine.
  • Participants will also carry global positioning system (GPS) units to record their locations during these 15 weeks, and will complete questionnaires about stress levels at specific intervals during the study.
  • At the end of the study, participants will have the choice of transferring to a community clinic or undergoing an 8-week taper from methadone.

Condition or disease
Cocaine Addiction Opiate Addiction

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 230 participants
Time Perspective: Prospective
Official Title: Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Study Start Date : August 15, 2003
Study Completion Date : June 11, 2013

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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

    1. Age between 18 and 65;
    2. Evidence of physical dependence on opioids (self-report and physical exam);
    3. Evidence of cocaine and opiate use (self-report and urine screen).



  1. Schizophrenia or any other DSM-IV psychotic disorder; history of bipolar disorder; current Major Depressive Disorder;
  2. Current dependence on alcohol or sedative-hypnotic, e.g. benzodiazepine (by DSM-IV criteria);
  3. Cognitive impairment severe enough to preclude informed consent or valid self-report;
  4. Medical illness that in the view of the investigators would compromise participation in research;
  5. Urologic conditions that would inhibit urine collection;
  6. In arm 2 only: current or recent maintenance on a methadone dose substantially higher than the arm 2 ceiling dose of 100 mg/day; the MRP will evaluate this case by case.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00292136

United States, Maryland
National Institute on Drug Abuse
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
Principal Investigator: Kenzie Preston, Ph.D. National Institute on Drug Abuse (NIDA)

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00292136     History of Changes
Other Study ID Numbers: 999903385
First Posted: February 15, 2006    Key Record Dates
Last Update Posted: April 5, 2018
Last Verified: June 11, 2013

Keywords provided by National Institutes of Health Clinical Center (CC):
Cocaine Dependence
Drug Relapse
Polydrug Abuse

Additional relevant MeSH terms:
Behavior, Addictive
Cocaine-Related Disorders
Opioid-Related Disorders
Compulsive Behavior
Impulsive Behavior
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders