Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis
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ClinicalTrials.gov Identifier: NCT00291863 |
Recruitment Status
: Unknown
Verified February 2006 by Federal University of São Paulo.
Recruitment status was: Recruiting
First Posted
: February 15, 2006
Last Update Posted
: February 16, 2006
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Renal Failure, End Stage Peritoneal Dialysis | Drug: Simvastatin | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 30 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double |
Primary Purpose: | Treatment |
Official Title: | Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis |
Study Start Date : | February 2006 |
Study Completion Date : | February 2006 |

- endothelial venodilation
- Inflammation markers (C-reactive protein, IL-6, TNF)
- Lipoproteins
- Oxidative stress

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Ages Eligible for Study: | 18 Years to 80 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- end stage renal failure
- peritoneal dialysis
- LDL cholesterol > 100mg/dL
- > 18 years and < 80 years
Exclusion Criteria:
- using statin or nitrate
- liver disease
- diabetes mellitus

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00291863
Contact: Maristela Bohlke, MD | 55 53 32264098 | mbohlke@conesul.com.br |
Brazil | |
São Lucas Hospital | Recruiting |
Porto Alegre, Rio Grande do Sul, Brazil | |
Principal Investigator: Carlos Eduardo P Figueiredo, PhD |
Principal Investigator: | Maristela Bohlke, master | Federal University of São Paulo |
ClinicalTrials.gov Identifier: | NCT00291863 History of Changes |
Other Study ID Numbers: |
0089/04 |
First Posted: | February 15, 2006 Key Record Dates |
Last Update Posted: | February 16, 2006 |
Last Verified: | February 2006 |
Keywords provided by Federal University of São Paulo:
end stage renal failure peritoneal dialysis simvastatin endothelium vasodilation |
Additional relevant MeSH terms:
Renal Insufficiency Kidney Failure, Chronic Kidney Diseases Urologic Diseases Renal Insufficiency, Chronic Simvastatin Anticholesteremic Agents |
Hypolipidemic Agents Antimetabolites Molecular Mechanisms of Pharmacological Action Lipid Regulating Agents Hydroxymethylglutaryl-CoA Reductase Inhibitors Enzyme Inhibitors |