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Inspiratory Muscle Training in Hypercapnic COPD

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2006 by Krankenhaus Kloster Grafschaft.
Recruitment status was:  Recruiting
Information provided by:
Krankenhaus Kloster Grafschaft Identifier:
First received: February 13, 2006
Last updated: August 18, 2006
Last verified: February 2006
The trial intends to investigate, whether inspiratory muscle training in hypercapnic patients improves inspiratory muscle strength, inspiratory muscle endurance and endurance to walk within six minutes.

Condition Intervention Phase
COPD Respiratory Failure Device: inspiratory muscle training Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Randomized Controlled Trial of Inspiratory Muscle Training in Patients With Stable Hypercapnic Respiratory Failure Due to COPD

Resource links provided by NLM:

Further study details as provided by Krankenhaus Kloster Grafschaft:

Primary Outcome Measures:
  • inspiratory muscle strength
  • inspiratory muscle endurance
  • walking distance with dyspnea score
  • Carbon dioxide level

Estimated Enrollment: 40
Study Start Date: February 2006
Estimated Study Completion Date: March 2008
Detailed Description:

Inspiratory muscle training is known to improve inspiratory muscle strength, inspiratory muscle endurance and walking distance within six minutes in patients with neuromuscular and thoraco-restrictive disease as well as in patients with COPD. Studies have only been conducted in patients without established respiratory failure. COPD patients with respiratory failure though are characterized by higher work rates of the inspiratory muscles and higher esophageal pressure swings compared to non-hypercapnic patients indication a discrepancy between muscle load and muscle capabilities. Therefore we hypothesize that for these patients training of their inspiratory muscles will be of benefit in terms of improvement of muscular and whole body endurance.

During this investigation inspiratory muscle training will be applied in a randomized controlled fashion in 40 patients over a period of four weeks parallel to physical rehabilitation.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • COPD with FEV1/FVC < 70 %
  • age > 18
  • stable disease
  • able to walk
  • carbon dioxide >= 48 mmHg

Exclusion Criteria:

  • ejection fraction of the heart < 40 %
  • active psychiatric disease
  • bronchial hyperresponsiveness according to ATS criteria
  • pregnancy
  • renal insufficiency with a creatinine < 2 mg/dl
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00291460

Contact: Dominic Dellweg, M.D. +49 2972 791 ext 1257

Fachkrankenhaus Kloster Grafschaft Recruiting
Schmallenberg, Germany, 57392
Contact: Dominic Dellweg, M.D.    +49 2972 ext 1257   
Principal Investigator: Dominic Dellweg, M.D.         
Sub-Investigator: Karina Reissig         
Sponsors and Collaborators
Krankenhaus Kloster Grafschaft
Principal Investigator: Dominic Dellweg, M.D. FKKG
Study Chair: Dieter Koehler, Prof. Dr. FKKG
  More Information Identifier: NCT00291460     History of Changes
Other Study ID Numbers: FKKG IMT 0106
Study First Received: February 13, 2006
Last Updated: August 18, 2006

Keywords provided by Krankenhaus Kloster Grafschaft:
respiratory failure
inspiratory muscle training

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes
Signs and Symptoms, Respiratory
Signs and Symptoms processed this record on September 18, 2017