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PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

This study has been terminated.
Information provided by:
Danish Headache Center Identifier:
First received: February 13, 2006
Last updated: October 25, 2006
Last verified: September 2005
Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Condition Intervention Phase
Headache Migraine Drug: PGI2 Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double

Resource links provided by NLM:

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:
  • Headache

Secondary Outcome Measures:
  • rCBF, blood flow, diameter of STA/RA, HR, BP

Estimated Enrollment: 12
Study Start Date: September 2005

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy volunteers,

Exclusion Criteria:

  • Primary headache,
  • headache on the day of investigation,
  • Hypertension,
  • hypotension,
  • pregnant/nursing
  • Daily intake of medication (except oral contraceptives)
  • Cardiovascular or CNS disease
  • Drug/Alcohol abuse
  • Psychiatric disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00291395

Danish Headache Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
Principal Investigator: Troels Wienecke, MD Danish Headache Center
  More Information Identifier: NCT00291395     History of Changes
Other Study ID Numbers: KA05055
Study First Received: February 13, 2006
Last Updated: October 25, 2006

Additional relevant MeSH terms:
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on September 19, 2017