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PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00291395
Recruitment Status : Terminated
First Posted : February 14, 2006
Last Update Posted : October 26, 2006
Information provided by:
Danish Headache Center

Brief Summary:
Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Condition or disease Intervention/treatment Phase
Headache Migraine Drug: PGI2 Phase 1

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Study Start Date : September 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Headache
U.S. FDA Resources

Primary Outcome Measures :
  1. Headache

Secondary Outcome Measures :
  1. rCBF, blood flow, diameter of STA/RA, HR, BP

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy volunteers,

Exclusion Criteria:

  • Primary headache,
  • headache on the day of investigation,
  • Hypertension,
  • hypotension,
  • pregnant/nursing
  • Daily intake of medication (except oral contraceptives)
  • Cardiovascular or CNS disease
  • Drug/Alcohol abuse
  • Psychiatric disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00291395

Danish Headache Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
Principal Investigator: Troels Wienecke, MD Danish Headache Center Identifier: NCT00291395     History of Changes
Other Study ID Numbers: KA05055
First Posted: February 14, 2006    Key Record Dates
Last Update Posted: October 26, 2006
Last Verified: September 2005

Additional relevant MeSH terms:
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms