Digestive and Nutritional Effects of Probiotics Supplementation in Premature Newborns
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Symbiotic interaction between probiotics ("Living alimentary microbials supplemental, affecting positively host by improving intestinal microbial equilibrium" (Fuller, 1989)) and human digestive tract was amply experimented and seems to be an interesting solution to orientate neonates digestive flora. Many studies showed a probant efficiency of probiotic supplementation in neonates on ECUN, despite abnormally high ECUN incidence in control group. Nevertheless, our aim is to test clinical efficiency of two new probiotics strains. Bifidobacterium Longum and Lactobacillus GG on Oral Nutrition (volume at Day 14 and Day 21) and safety (Adverse Events) in very premature babies.
Condition or disease
Duration of Parenteral Nutrition
Dietary Supplement: Probiotics supplementation until weight reaches 1800g (Bifidobacterium Longum and Lactobacillus GG )
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Ages Eligible for Study:
up to 2 Weeks (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
newborns (< 2 weeks of life)
32 Weeks of Gestation,
weight < 1500g,
Enteral nutrition begun,
Signed consent form from both parents.
newborns (>= 2 weeks of life),
weight >= 1500g,
pathology avoiding the start of the enteral nutrition,
other pathologies of those due to premature and its complications,