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The Effect of Positive Airway Pressure on Heart Rate Variability

This study has been completed.
Information provided by (Responsible Party):
Raelene Maser, Christiana Care Health Services Identifier:
First received: February 9, 2006
Last updated: July 7, 2016
Last verified: September 2008
This study is designed to determine the effect of continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP) on heart rate variability (HRV) in patients with obstructive sleep apnea (OSA).

Obstructive Sleep Apnea

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: A Prospective Study to Determine the Effect of Positive Airway Pressure on Heart Rate Variability in Individuals With Obstructive Sleep Apnea

Resource links provided by NLM:

Further study details as provided by Christiana Care Health Services:

Biospecimen Retention:   Samples Without DNA
Serum, Plasma, Urine

Estimated Enrollment: 38
Study Start Date: July 2003
Study Completion Date: September 2008
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Tertiary Care

Inclusion Criteria:

  • Individuals aged 18-75 years old.
  • Individuals with diagnosed OSA.

Exclusion Criteria:

  • 1. Individuals who are receiving treatment for OSA, excluding those being treated by weight loss.

    2. Individuals who have had pharyngeal surgery (i.e., uvulopalatopharyngoplasty).

    3. Individuals who have arterial oxygen desaturation episodes or apneic episodes not felt to be due to OSA.

    4. Individuals whose treatment dosage changes 2 months prior to, or during, the study for antihypertensive and antidiabetic medications and the following medications that may affect the autonomic nervous system: anti-tuberculosis drugs, nitrofurantoin, metronidazole, chloramphenicol, perhexiline maleate, cordarone, clofibrate, tricyclic antidepressants, phenytoin, barbiturates, neuroleptic drugs, antiparkinsonism drugs, and nitrated drugs.

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Please refer to this study by its identifier: NCT00289666

United States, Delaware
Christiana Care Health Service
Newark, Delaware, United States, 19713
Sponsors and Collaborators
Christiana Care Health Services
Principal Investigator: Raelene E Maser, PhD University of Delaware
  More Information

Responsible Party: Raelene Maser, Associate Professor, Christiana Care Health Services Identifier: NCT00289666     History of Changes
Other Study ID Numbers: 23011
Study First Received: February 9, 2006
Last Updated: July 7, 2016

Keywords provided by Christiana Care Health Services:
Sleep Disorder

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on April 25, 2017