Natural History Study of Moles and Suspicious Melanoma
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|ClinicalTrials.gov Identifier: NCT00288938|
Recruitment Status : Completed
First Posted : February 8, 2006
Last Update Posted : July 2, 2017
- Melanocytic nevi, or "moles," are non-cancerous growths of a type of skin cell called a melanocyte.
- Large congenital melanocytic nevi (LCMN) are a special type of mole that begins to grow before birth and is larger than moles that develop after birth.
- Determining how melanocytes in moles and LCMNs differ from normal melanocytes may increase the ability to predict whether a mole will give rise to a melanoma (a type of skin cancer)
- To understand how melanomas develop, by studying moles, LCMNs, and pigmented skin lesions that are suspicious for melanoma
- To develop better criteria for diagnosing melanoma, particularly by using a device called a digital dermatoscope (a special camera, connected to a computer, that takes pictures of moles when they are magnified and illuminated)
- Children 5 years old or older with an LCMN
- Adults 18 years old or older with 100 or more moles larger than 2 mm in diameter and at least one 4 mm or more
- Adults 18 years old or older with a pigmented lesion suspicious for melanoma
- Patients' personal and family health history is obtained.
- Patients are examined by investigative team doctors, and several lesions are examined with a dermatoscope.
- Additional photographs of part or all of the skin surface may be taken.
- Some lesions may be biopsied.
- Additional tests or examinations may be recommended.
- Patients are followed periodically for skin or physical examinations, photography, laboratory and imaging evaluations, and possible skin biopsies.
- Children may undergo brain magnetic resonance imaging (MRI)
|Condition or disease|
|Melanocytic Nevi Acquired Melanocytic Nevi Primary Cutaneous Melanoma|
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Dermoscopic Diagnosis, Histopathological Correlation, and Cellular Immortalization of Melanocytic Nevi and Primary Cutaneous Melanoma|
|Study Start Date :||February 3, 2006|
|Study Completion Date :||October 31, 2011|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00288938
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|