Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis
Recurrent aphthous stomatitis is a common phenomenon in Primary Medicine.Frequency of the phenomenon can be as high as 25% of the general population and the recurrence of the problem can be up to 50%.Different approaches for treatment are described: treatment with various natural vitamins , local ointments , disinfectant agents for local treatment , local antibiotic ointments , NSAID, local cortisone-steroids , and even medication on the basis of immune-depressants of the immune system and systematic steroids .
A double-blind study of daily administration of sublingual Vitamin B12 tablets manufactured by Solgar (each tablet containing 1000 mcg. of Vitamin B12) opposed to placebo tablets.
Purpose of the research:
To investigate the effect of Vitamin B12 on the frequency of recurrent canker sores of the mouth (RAS).
Treatment with vitamin B12 will reduce the recurrence rate and will diminish the symptomatology of RAS episodes.
|Recurrent Aphthous Stomatitis||Drug: daily sublingual tablets Vitamin B12 1000 mcg versus placebo|
|Study Design:||Allocation: Randomized
Intervention Model: Single Group Assignment
Primary Purpose: Treatment
Please refer to this study by its ClinicalTrials.gov identifier: NCT00288769
|Ben-Gurion University of the Negev|
|Beer Sheva, Israel|
|Principal Investigator:||Ilia Volkov, MD||Ben-Gurion University of the Negev|