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The V-Tachogram:Decreasing Ventricular Arrythmias When Injecting Contrast in the Left Ventricle

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ClinicalTrials.gov Identifier: NCT00288756
Recruitment Status : Unknown
Verified September 2006 by Trillium Health Centre.
Recruitment status was:  Active, not recruiting
First Posted : February 8, 2006
Last Update Posted : September 13, 2006
Information provided by:
Trillium Health Centre

Brief Summary:
The purpose of this study is to determine if increasing the linear rise rate of injection of x-ray contrast in the heart during left ventriculograms(part of a cardiac Catheterization procedure) will decrease the incidence of arrythmias and improve image quality?

Condition or disease Intervention/treatment Phase
Ventricular Arrythmias Procedure: lv injection of contrast Phase 1

Detailed Description:

The LV angiogram is performed frequently as part of the cardiac catheterization procedure. It is done by injecting a bolus of x-ray contrast into the ventricle through a pigtail catheter over a short period of time and observing the heart as it is pumped out. This provides information on regional wall motion abnormalities, ejection fraction, and mitral regurgitation. A common occurrence when performing a LV angio is frequent PVC’s or V-tach during the injection, it has been suggested that ectopic's occurs about 54% of the time and that interpretability was limited 30% of the time(3) This is rarely serious and subsides at the end of the injection but the irregularity of the contractions does affect the diagnostic quality of the exam.

In an attempt to decrease the incidence of ventricular ectopic's during the LV angiogram Contrast injections with a greater linear rise increasing the injection duration to at least ½ the flow rate, greater than previous settings should decrease the tension and the contrast jets coming out of the catheter, decreasing the fling of the catheter at the initiation of the injection. Whether this affects the quality of the angiogram with a pig tail vs. a straight catheter will also need to be considered?

Study Type : Observational
Estimated Enrollment : 156 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Study Start Date : July 2006
Estimated Study Completion Date : August 2006

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Only ventriculograms that the operator deems necessary for the booked procedure will be considered. Only operators agreeing to the for mentioned settings will participate in the study. Patients will be randomized consecutively and should conclude in 3 to 4 weeks.

Exclusion Criteria:

  • Patients with aortic valve disease, a-fib, and frequent benign ectopic beats and patients unable to follow instructions to stop breathing will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00288756

Canada, Ontario
Trillium Health Centre
Mississauga, Ontario, Canada, L5B 1B8
Sponsors and Collaborators
Trillium Health Centre
Principal Investigator: Peter Vandermyden, RN staff RN Trillium Health Centre

ClinicalTrials.gov Identifier: NCT00288756     History of Changes
Other Study ID Numbers: 01
First Posted: February 8, 2006    Key Record Dates
Last Update Posted: September 13, 2006
Last Verified: September 2006

Keywords provided by Trillium Health Centre: