This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating (METRAPI)

This study has been completed.
Information provided by:
University Hospital, Tours Identifier:
First received: February 3, 2006
Last updated: March 16, 2010
Last verified: March 2010
Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.

Condition Intervention
Post-Traumatic Stress Disorders Anxiety Amnesia, Dissociative Procedure: Magnetic Resonance Imaging, Functional

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Working Memory Updating in Posttraumatic Stress Disorder (PTSD): Study of Neural Correlates Using fMRI

Resource links provided by NLM:

Further study details as provided by University Hospital, Tours:

Enrollment: 34
Study Start Date: January 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
PTSD Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI
CONTROLS Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI

Detailed Description:
Working memory performance will be assessed using the "3-back test", and processing speed evaluated with "words comparison test". The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
PTSD related to sexual abuse vs controls, in right-handed females.

Inclusion Criteria:

  • Right-handed women
  • Victim of sexual abuse
  • Suffering from PTSD

Exclusion Criteria:

  • Epilepsy
  • Claustrophobia
  • MRI contre-indication
  • Addictive disorders
  • Sightless
  • Detection of a brain injury at the MRI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00288314

University Hospital of Tours
Tours, Centre, France, 37044
Sponsors and Collaborators
University Hospital, Tours
Principal Investigator: Wissam EL HAGE, MD, PhD UNIVERSITY HOSPITAL OF TOURS
  More Information

Responsible Party: PHRR, CHRU TOURS Identifier: NCT00288314     History of Changes
Other Study ID Numbers: PHRR04-WEH/METRAPI
Study First Received: February 3, 2006
Last Updated: March 16, 2010

Keywords provided by University Hospital, Tours:
MRI, Functional
Working Memory
Processing speed

Additional relevant MeSH terms:
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Pathologic Processes
Trauma and Stressor Related Disorders
Mental Disorders
Memory Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Neurocognitive Disorders processed this record on August 17, 2017