Autoimmune Hepatitis Study

This study has been terminated.
(Principal Investigator moving out of state, no other staff to lead research.)
National Institutes of Health (NIH)
Information provided by:
University of Rochester Identifier:
First received: February 1, 2006
Last updated: July 8, 2008
Last verified: July 2008

The purpose of the study is to determine the role special antibodies play in possibly identifying Autoimmune Hepatitis through the following:

Identify the response of specific T cells to antibodies and Monitor the response of the cells that regulate the immune system

Condition Phase
Hepatitis, Autoimmune
Phase 1

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Evaluation of the Cellular Immune Response in Patients With Anti-SLA/LP- or Anti-LKM-Positive Autoimmune Hepatitis

Resource links provided by NLM:

Further study details as provided by University of Rochester:

Estimated Enrollment: 100
Study Start Date: January 2006
Study Completion Date: June 2008
Detailed Description:
The object of this protocol is to characterize and monitor auto antigen-specific T cell responses in blood and liver biopsies of patients with anti-SLA/LP or anti-LKM-positive autoimmune hepatitis. The results will provide insight into the pathogenesis of autoimmune hepatitis and the monitoring of auto antigen-specific T cell reactivity in correlation to disease exacerbation and therapy.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Male or female subjects,All ethnic groups, Over 18 years of age, anti-SLA/LP or anti-LKM-positive autoimmune hepatitis

Exclusion Criteria:

Subjects with a hematocrit of <25

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00286663

Sponsors and Collaborators
University of Rochester
National Institutes of Health (NIH)
Principal Investigator: Parvez S Mantry, MD University of Rochester
  More Information

Responsible Party: Parvez S. Mantry, MD, University of Rochester Medical Center Liver and Digestive Disease Unit Identifier: NCT00286663     History of Changes
Other Study ID Numbers: RSRB 12494 
Study First Received: February 1, 2006
Last Updated: July 8, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by University of Rochester:
AIH, Autoimmune Hepatitis

Additional relevant MeSH terms:
Hepatitis, Autoimmune
Hepatitis A
Autoimmune Diseases
Digestive System Diseases
Enterovirus Infections
Hepatitis, Chronic
Hepatitis, Viral, Human
Immune System Diseases
Liver Diseases
Picornaviridae Infections
RNA Virus Infections
Virus Diseases processed this record on May 23, 2016