Long-term Mortality in Diabetics Undergoing Major Surgery
Patients with CAD and diabetes mellitus have a better prognosis than patients with CAD and no diabetes mellitus. In acute coronary syndrome patients with an insulin therapy had a better survival than patients with oral antidiabetics. But there is not known wether perioperative therapy with insulin or oral antidiabetics is associated with higher risk for higher perioperative cardiac morbidity and mortality and worse long-term survival.
Coronary Heart Disease
Major Non-cardiac Surgery
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Comparison in Survival in Patients With Insulin-dependent and Non-insulin-dependent Diabetes Mellitus With Known or Suspected Coronary Artery Disease Undergoing Major Non-cardiac Surgery|
- Death and/or major adverse cardiac events [ Time Frame: 12 months after surgery ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2004|
|Study Completion Date:||August 2010|
|Primary Completion Date:||August 2009 (Final data collection date for primary outcome measure)|
Diabetes mellitus is an important risk factor for arteriosclerosis in general and for coronary artery disease. Patients with CAD have a worse prognosis if they have diabetes mellitus. But it is not known whether the treatment of Dm has an influence on mortality or morbidity.
In face of the high number of patients with Dm and the therapeutic consequences this prospective study wants to compare short-time and long-time morbidity in Patients with Dm undergoing major non-vascular surgery. Inclusion criteria are medically treated Dm (insulin or oral antidiabetics) and major non cardiac surgery.
The "normal" perioperative treatment of the study is not changed by the study itself.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00286572
|Basel, CH, Switzerland, 4000|
|Principal Investigator:||Miodrag Filipovic, PD Dr.||University Hospital, Basel, Switzerland|