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Early Exposure to Lead and Adult Antisocial Outcomes

This study has been completed.
Information provided by (Responsible Party):
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: February 1, 2006
Last updated: November 17, 2014
Last verified: November 2014
Prior research indicates a link between early lead exposure and risk for delinquent behavior. In this study, we follow a large birth cohort from the Cincinnati Lead Study into early adulthood to determine whether this increased risk persists. Outcome measures include official arrest records, diagnoses of Substance Abuse Disorder and Antisocial Personality Disorder, self-report of delinquent behavior, and a psychopathy scale. Predictors include pre-natal and post-natal blood lead levels. Multivariate statistical methods will control for potential confounders/covariates.

Lead Poisoning

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Primary Outcome Measures:
  • Lead Exposure and Antisocial Behavior [ Time Frame: Prenatal (1-2 trimester) and postnatal on a quarterly and bi-annual basis (until 6.5 years) ]

Estimated Enrollment: 225
Study Start Date: November 2001
Study Completion Date: October 2006
Primary Completion Date: October 2006 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Pregnant women were recruited from four prenatal clinics in Cincinnati, Ohio if they resided in areas of the city with a high concentration of older, lead-contaminated housing

Inclusion Criteria: (1) Part of original CLS birth cohort -

Exclusion Criteria: (1) Moved out of geographic area

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00285610

United States, Ohio
Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Principal Investigator: M. Douglas Ris, Ph.D. Children's Hospital Medical Center, Cincinnati
  More Information

Responsible Party: National Institute of Environmental Health Sciences (NIEHS) Identifier: NCT00285610     History of Changes
Other Study ID Numbers: 11261-CP-003
Study First Received: February 1, 2006
Last Updated: November 17, 2014

Additional relevant MeSH terms:
Lead Poisoning
Chemically-Induced Disorders processed this record on September 19, 2017