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Early Exposure to Lead and Adult Antisocial Outcomes

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00285610
First Posted: February 2, 2006
Last Update Posted: November 18, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
Prior research indicates a link between early lead exposure and risk for delinquent behavior. In this study, we follow a large birth cohort from the Cincinnati Lead Study into early adulthood to determine whether this increased risk persists. Outcome measures include official arrest records, diagnoses of Substance Abuse Disorder and Antisocial Personality Disorder, self-report of delinquent behavior, and a psychopathy scale. Predictors include pre-natal and post-natal blood lead levels. Multivariate statistical methods will control for potential confounders/covariates.

Condition
Lead Poisoning

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Primary Outcome Measures:
  • Lead Exposure and Antisocial Behavior [ Time Frame: Prenatal (1-2 trimester) and postnatal on a quarterly and bi-annual basis (until 6.5 years) ]

Estimated Enrollment: 225
Study Start Date: November 2001
Study Completion Date: October 2006
Primary Completion Date: October 2006 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Pregnant women were recruited from four prenatal clinics in Cincinnati, Ohio if they resided in areas of the city with a high concentration of older, lead-contaminated housing
Criteria

Inclusion Criteria: (1) Part of original CLS birth cohort -

Exclusion Criteria: (1) Moved out of geographic area

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00285610


Locations
United States, Ohio
Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Investigators
Principal Investigator: M. Douglas Ris, Ph.D. Children's Hospital Medical Center, Cincinnati
  More Information

Responsible Party: National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier: NCT00285610     History of Changes
Other Study ID Numbers: 11261-CP-003
First Submitted: February 1, 2006
First Posted: February 2, 2006
Last Update Posted: November 18, 2014
Last Verified: November 2014

Additional relevant MeSH terms:
Poisoning
Lead Poisoning
Chemically-Induced Disorders