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Biomagnetic Signals of Intestinal Ischemia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00285545
First Posted: February 2, 2006
Last Update Posted: July 2, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
William Richards, University of South Alabama
  Purpose
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

Condition Phase
Ischemia Phase 1

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Biomagnetic Signals of Intestinal Ischemia II

Further study details as provided by William Richards, University of South Alabama:

Primary Outcome Measures:
  • To observe a difference in the magnetic activity between normal and diseased smooth muscle [ Time Frame: 2011 ]

Enrollment: 60
Study Start Date: January 2000
Study Completion Date: January 2013
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Good blood flow
Group with normal blood flow to small intestine
Poor blood flow
Group with partial ischemia to small intestine

Detailed Description:
The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, we hope to identify abnormal disease states without surgery.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary Care Clinic
Criteria

Inclusion Criteria:

  • Normal Subjects and those diagnosed with mesenteric ischemia

Exclusion Criteria:

  • Subjects who report a tendency toward claustrophobia
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00285545


Locations
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
University of South Alabama
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: William O Richards, MD Vanderbilt University Medical Center
  More Information

Responsible Party: William Richards, principal investigator, University of South Alabama
ClinicalTrials.gov Identifier: NCT00285545     History of Changes
Other Study ID Numbers: DK58197
R01DK058197 ( U.S. NIH Grant/Contract )
First Submitted: January 31, 2006
First Posted: February 2, 2006
Last Update Posted: July 2, 2013
Last Verified: June 2013

Keywords provided by William Richards, University of South Alabama:
Blood Supply
Mesentery

Additional relevant MeSH terms:
Ischemia
Pathologic Processes