Japan Morning Surge-1 Study
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00285519 |
Recruitment Status :
Completed
First Posted : February 2, 2006
Last Update Posted : February 2, 2006
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Hypertension | Drug: Doxazosin (drug) | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 600 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | The Effects of Controlling Morning Hypertension on Target Organ Damage With Adrenergic Blockers, Based on Self-Measured Morning Blood Pressure Readings |
Study Start Date : | August 2003 |
Study Completion Date : | August 2005 |

- brain natriuretic peptide and the urinary albumin excretion/creatinine ratio at 6 months

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Morning systolic blood pressure >135 mmHg in a sitting position at home while on stable antihypertensive medication for at least 3 months
Exclusion Criteria:
- History of heart failure
- Presence of orthostatic hypotension, dementia, malignancy and chronic inflammatory disease
- Taking an alfa-blocker or beta-blocker
- Atrial fibrillation or atrial flutter

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00285519
Japan | |
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine | |
Shimotsuke, Tochigi, Japan, 329-0498 |
Study Chair: | Kazuomi Kario, MD, PhD | Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00285519 |
Other Study ID Numbers: |
JHF-03-143 |
First Posted: | February 2, 2006 Key Record Dates |
Last Update Posted: | February 2, 2006 |
Last Verified: | February 2006 |
Morning hypertension |
Hypertension Vascular Diseases Cardiovascular Diseases Doxazosin Antihypertensive Agents Adrenergic alpha-1 Receptor Antagonists |
Adrenergic alpha-Antagonists Adrenergic Antagonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs |