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The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2005 by Johns Hopkins University.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00284726
First Posted: February 1, 2006
Last Update Posted: February 1, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Johns Hopkins University
  Purpose
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Condition Intervention Phase
Lung Transplant Recipients Device: Celsior Cold Storage Solution Phase 3

Study Type: Interventional
Official Title: A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation

Resource links provided by NLM:


Further study details as provided by Johns Hopkins University:

Study Start Date: December 2000
Estimated Study Completion Date: September 2005
Detailed Description:
The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Criteria

Inclusion Criteria:

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00284726


Sponsors and Collaborators
Johns Hopkins University
Investigators
Principal Investigator: John V. Conte, M.D. Johns Hopkins University
  More Information

ClinicalTrials.gov Identifier: NCT00284726     History of Changes
Other Study ID Numbers: 00-10-25-03
First Submitted: January 31, 2006
First Posted: February 1, 2006
Last Update Posted: February 1, 2006
Last Verified: August 2005

Keywords provided by Johns Hopkins University:
Cytokines in lung transplantation
Cold storage solutions
Ischemic reperfusion injury

Additional relevant MeSH terms:
Pharmaceutical Solutions