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The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

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ClinicalTrials.gov Identifier: NCT00284726
Recruitment Status : Completed
First Posted : February 1, 2006
Last Update Posted : December 7, 2017
Sponsor:
Information provided by:
Johns Hopkins University

Brief Summary:
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Condition or disease Intervention/treatment Phase
Lung Transplant Recipients Device: Celsior Cold Storage Solution Phase 3

Detailed Description:
The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.

Study Type : Interventional  (Clinical Trial)
Official Title: A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation
Study Start Date : December 2000
Study Completion Date : September 2005

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U.S. FDA Resources





Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Criteria

Inclusion Criteria:

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion Criteria:


Information from the National Library of Medicine

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00284726


Sponsors and Collaborators
Johns Hopkins University
Investigators
Principal Investigator: John V. Conte, M.D. Johns Hopkins University

ClinicalTrials.gov Identifier: NCT00284726     History of Changes
Other Study ID Numbers: 00-10-25-03
First Posted: February 1, 2006    Key Record Dates
Last Update Posted: December 7, 2017
Last Verified: December 2017

Keywords provided by Johns Hopkins University:
Cytokines in lung transplantation
Cold storage solutions
Ischemic reperfusion injury

Additional relevant MeSH terms:
Pharmaceutical Solutions