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Pro-Calcitonin Levels Following Pediatric Cardiac Surgery

This study has been completed.
Children's Healthcare of Atlanta
Information provided by (Responsible Party):
Kevin O. Maher, MD, Emory University Identifier:
First received: January 30, 2006
Last updated: November 26, 2013
Last verified: November 2013

First, we, the researchers, hope to find out the PCT response to heart surgery in children by taking blood before surgery and each day for four days after surgery. These blood draws will help us figure out the typical Procalcitonin (PCT) response, the normal increase in PCT after heart surgery, and when the PCT level returns to baseline.

Second, we, the researchers, hope to determine the accuracy of PCT as a marker of infection.


Our hypothesis is that Procalcitonin is superior to other currently used markers of infection and will prove to be a clinically useful tool for evaluation of infection in children following cardiac surgery.

Congenital Heart Disease

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: ProCalcitonin in the Pediatric Surgical Patient, Evaluation of a New Marker of Infection

Further study details as provided by Emory University:

Biospecimen Retention:   Samples With DNA
Blood samples are collected in order to get the procalcitonin level.

Enrollment: 49
Study Start Date: January 2006
Study Completion Date: March 2007
  Show Detailed Description


Ages Eligible for Study:   up to 5 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study patients will be recruited from Children's Healthcare of Atlanta at Egleston. The patients will be in the pre-operative clinic, Cardiac Intensive Care Unit or the Cardiac Stepdown Unit.

Inclusion Criteria:

  • Patients with congenital heart disease
  • Undergoing cardiopulmonary bypass and cardiac surgery
  • Newborn (full term) to up to 6 years of age

Exclusion Criteria:

  • Premature (less than 37 weeks)
  • 6 years of age or older
  • Intercurrent illness at time of surgery
  • Orthotopic organ transplant recipient
  • Pre-operative extra-corporeal support (ECMO)
  • Acquired heart disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00284570

United States, Georgia
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
Children's Healthcare of Atlanta
Principal Investigator: Kevin Maher, MD Emory University
  More Information

Responsible Party: Kevin O. Maher, MD, Associate Prefessor of Pediatrics, Emory University Identifier: NCT00284570     History of Changes
Other Study ID Numbers: IRB00002022
Study First Received: January 30, 2006
Last Updated: November 26, 2013

Keywords provided by Emory University:
congenital heart disease
cardiopulmonary bypass
marker for infection
cardiac surgery

Additional relevant MeSH terms:
Communicable Diseases
Heart Diseases
Heart Defects, Congenital
Cardiovascular Diseases
Systemic Inflammatory Response Syndrome
Pathologic Processes
Cardiovascular Abnormalities
Congenital Abnormalities processed this record on April 28, 2017