Choroidal Blood Flow Response to Hand-grip Test in Progressive Glaucoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

ClinicalTrials.gov Identifier: NCT00284440

Recruitment Status : Withdrawn (enrollment problems)

First Posted : January 31, 2006

Last Update Posted : March 10, 2015

Sponsor:

Information provided by (Responsible Party):

University Hospital, Basel, Switzerland

Study Description

Brief Summary:

The present study is designed to compare the response of choroidal blood flow to the hand-grip test in glaucoma patients with and without visual field progression.

Condition or disease
Primary Open Angle Glaucoma

Detailed Description:

Glaucoma is a worldwide leading cause of blindness. The key features of glaucoma are damage to the optic nerve head and progressive visual field defect, which is not necessarily only related to an increase in intraocular pressure. It has been suggested that ocular blood flow alterations in glaucoma are related to systemic vascular dysregulations.The hand-grip test has been suggested as a potential tool to unravel vascular dysregulation in the ocular circulation. Although applied routinely in clinical practice, a proper study testing the effectiveness of this test is lacking. The present study is designed to compare the response of choroidal blood flow to the hand-grip test in glaucoma patients with and without visual field progression.

Study Design


Study Type :	Observational
Actual Enrollment :	0 participants
Observational Model:	Case-Only
Time Perspective:	Prospective
Official Title:	Relationship Between Visual Field Progression in Glaucoma and Choroidal Blood Flow Response to the Hand-grip Test
Study Start Date :	March 2006
Actual Primary Completion Date :	June 2011
Actual Study Completion Date :	June 2011

Resource links provided by the National Library of Medicine

Genetics Home Reference related topics: Early-onset glaucoma

MedlinePlus related topics: Flu Glaucoma

Genetic and Rare Diseases Information Center resources: Pigment-dispersion Syndrome

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:	30 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

patients with glaucoma

Criteria

Inclusion Criteria: Patients fulfilling two out of three of the following criteria in one or both eyes: a) typical glaucomatous disc, b) visual field damage (a cluster of three points (except rim points) in at least one hemifield reduced by 5 dB or greater and including at least one point reduced by 10 dB or greater; a cluster of two points reduced by 10 dB or greater; or three adjacent points on the nasal horizontal meridian that differed by 5 dB or greater from their mirror points on the opposite side of the meridian), c) intraocular pressure above 21 mm Hg at least at one occasion. Furthermore, patients need to have a series of at least 5 visual field examinations, after exclusion of the first test, for assessment of progression.

Exclusion Criteria:

Ametropia > 3dpt
Inadequate transparency of ocular media as defined by physical examination
Iridocorneal angle extremely narrow with complete or partial closure as determined by gonioscopy
Any abnormality which in the physician's view would prevent reliable applanation tonometry or LDF of at least one eye
History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis
History of ocular trauma or intraocular surgery within the past 6 months
History of infection or inflammation within the past 3 months
History of clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment
Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study).

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00284440

Locations


Switzerland
University Eye Clinic
Basel, BS, Switzerland, 4031

Sponsors and Collaborators

University Hospital, Basel, Switzerland

Investigators


Principal Investigator:	Selim Orguel, MD	Chief of department of diagnostics

More Information

Publications:

Gugleta K, Orgül S, Hasler PW, Picornell T, Gherghel D, Flammer J. Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1573-80.


Responsible Party:	University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:	NCT00284440 History of Changes
Other Study ID Numbers:	072-Leh-2005-001
First Posted:	January 31, 2006 Key Record Dates
Last Update Posted:	March 10, 2015
Last Verified:	March 2015

Keywords provided by University Hospital, Basel, Switzerland:


Visual field progression Choroidal blood flow

Additional relevant MeSH terms:


Glaucoma Glaucoma, Open-Angle Ocular Hypertension Eye Diseases

To Top