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PEEP Test and Gas Exchange in ALI/ARDS Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00284102
First Posted: January 31, 2006
Last Update Posted: September 25, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Policlinico Hospital
  Purpose
The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.

Condition Intervention
Acute Respiratory Distress Syndrome Procedure: Mechanical ventilation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Positive End Expiratory Pressure (PEEP) Test and Gas Exchange in ALI/ARDS Patients

Resource links provided by NLM:


Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:
  • Gas exchange, dead space, respiratory mechanics [ Time Frame: 5, 15, 30, 60 minutes from PEEP change ]

Enrollment: 50
Study Start Date: January 2006
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
ALI/ARDS patients
Procedure: Mechanical ventilation
measurement of gas exchange, dead space, respiratory mechanics 5, 15, 30, 60 minutes from PEEP change (5 and 15 cmH2O)

Detailed Description:
In a population of ALI/ARDS patients during mechanical ventilation we will evaluate the effect of different levels of PEEP on gas exchange and dead space.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ALI/ARDS patients requiring mechanical ventilation

Exclusion Criteria:

  • Hemodynamic instability
  • Barotrauma
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00284102


Locations
Italy
Policlinico Hospital
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Investigators
Principal Investigator: Davide Chiumello, MD Policlinico Hospital
  More Information

Responsible Party: Davide Chiumello, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00284102     History of Changes
Other Study ID Numbers: 1700
First Submitted: January 30, 2006
First Posted: January 31, 2006
Last Update Posted: September 25, 2008
Last Verified: September 2008

Keywords provided by Policlinico Hospital:
gas exchange
dead space
respiratory failure
ALI/ARDS patients

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury