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New Strategies for Non-invasive Detection of Chronic Allograft Nephropathy

This study has been completed.
Hoffmann-La Roche
Information provided by (Responsible Party):
Virginia Commonwealth University Identifier:
First received: January 25, 2006
Last updated: March 16, 2017
Last verified: March 2017
The purpose of this study is to help researchers find out more about a condition called "Chronic Allograft Nephropathy" (CAN). CAN is a complication that sometimes occurs after kidney transplantation and affects the function of the transplanted kidney. It is hoped that by studying blood, urine, and tissue samples of kidney transplant patients, new ways of diagnosing and treating CAN may be found.

Chronic Rejection

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: New Strategies for Non-invasive Detection of Chronic Allograft Nephropathy

Resource links provided by NLM:

Further study details as provided by Virginia Commonwealth University:

Biospecimen Retention:   Samples With DNA
Blood, Urine

Enrollment: 121
Study Start Date: January 2006
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients Diagnosis of Chronic Allograft Nephropathy at VCUHS Clinic

Inclusion Criteria:

  • Received primary kidney transplant Diagnosis of Chronic Allograft Nephropathy Stable immunosuppression for one month prior to entry

Exclusion Criteria:

  • Serious comorbidity Pregnancy Retransplantation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00283348

United States, Virginia
VCU Health System
Richmond, Virginia, United States, 23298
Sponsors and Collaborators
Virginia Commonwealth University
Hoffmann-La Roche
Principal Investigator: Daniel G Maluf, MD Virginia Commonwealth University
Principal Investigator: Valeria Mas, Ph.D. Virginia Commonwealth University
  More Information

Responsible Party: Virginia Commonwealth University Identifier: NCT00283348     History of Changes
Other Study ID Numbers: Cell 500
Study First Received: January 25, 2006
Last Updated: March 16, 2017

Keywords provided by Virginia Commonwealth University:
Renal Transplantation
Chronic Rejection processed this record on May 25, 2017