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Oligodendrocyte Progenitor Cell Culture From Human Brain

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ClinicalTrials.gov Identifier: NCT00283023
Recruitment Status : Unknown
Verified August 2008 by Rajavithi Hospital.
Recruitment status was:  Recruiting
First Posted : January 27, 2006
Last Update Posted : August 5, 2008
Information provided by:

Study Description
Brief Summary:
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.

Condition or disease Intervention/treatment Phase
Demyelinating Diseases Procedure: Oligodendrocyte progenitor cell culture/craniotomy Phase 1

Detailed Description:
Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Phase 1: Oligodendrocyte Progenitor Cell Culture From Human Brain
Study Start Date : December 2007
Estimated Primary Completion Date : December 2010
Arms and Interventions

Arm Intervention/treatment
Experimental: A
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
Procedure: Oligodendrocyte progenitor cell culture/craniotomy
Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply
Other Name: Rajavithi Oligodendrocyte progenitor cell culture protocol

Outcome Measures

Primary Outcome Measures :
  1. Number of oligodendrocyte progenitor cell differentiation [ Time Frame: one month ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male or female 20-65 years of age
  • Informed consent
  • Has elective craniotomy surgery

Exclusion Criteria:

  • HIV, hepatitis, and other central nervous system (CNS) infections
  • Dementia, Alzheimer disease, and neurodegenerative disease
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00283023

Contact: Subsai Kongsaengdao, M.D. +66-6-6596159 skhongsa@gmail.com

Assistant Professor Subsai Kongsaengdao Recruiting
Bangkok, Thailand, 10400
Contact: Subsai Kongsaengdao, M.D.    66-86-6596159    skhongsa@gmail.com   
Contact: Piyathida Boontee, M.D.    66-81-8423854    pboontee@yahoo.com   
Sponsors and Collaborators
Rajavithi Hospital
Principal Investigator: Subsai Kongsaengdao, M.D. Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand
More Information

Responsible Party: Assistant Professor Subsai Kongsaengdao, Rajavithi Hospital
ClinicalTrials.gov Identifier: NCT00283023     History of Changes
Other Study ID Numbers: RH-CMR-003
RVH-CMR-003 grant
First Posted: January 27, 2006    Key Record Dates
Last Update Posted: August 5, 2008
Last Verified: August 2008

Keywords provided by Rajavithi Hospital:
All selective craniotomy

Additional relevant MeSH terms:
Demyelinating Diseases
Nervous System Diseases