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High-protein and High-carbohydrate Diets' Effect on Urinary Concentrating Ability

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ClinicalTrials.gov Identifier: NCT00282321
Recruitment Status : Completed
First Posted : January 26, 2006
Last Update Posted : February 22, 2010
Information provided by:
Regional Hospital Holstebro

Brief Summary:
We wanted to test urinary concentrating ability and AQP-2 expression in kidney during high-protein and high-carbohydrate diet.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: High Protein diet Behavioral: High carbohydrate diet Phase 4

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : May 2007
Primary Completion Date : May 2009
Study Completion Date : June 2009

Primary Outcome Measures :
  1. u-AQP-2
  2. FeNa+

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • (1) Genders; both mal and female
  • (2) Age; 18- 65 years old
  • (3) BMI; below 30
  • (4) Females had to bee in oral contraceptive treatment

Exclusion Criteria:

  • (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs
  • (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)
  • (3) Albuminuria or glucosuria
  • (4) Cancer
  • (5) Arterial hypertension
  • (6) Alcohol abuse
  • (7) Use of tobacco
  • (8) Medical treatment, except oral contraceptives
  • (9) Pregnancy or breast feeding
  • (10) Medicine abuse
  • (11) Donation of blood less than 1 month before the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00282321

Department of Medicine, Holstebro Hospital
Holstebro, Denmark
Sponsors and Collaborators
Regional Hospital Holstebro
Study Chair: Erling B Pedersen, Professor Holstebro Hospital, 7500 Holstebro Denmark
Principal Investigator: Thomas G Knudsen, MD Holstebro Hospital, 7500 Holstebro, Denmark

ClinicalTrials.gov Identifier: NCT00282321     History of Changes
Other Study ID Numbers: MED.RES.HOS.2006.01.TGK
First Posted: January 26, 2006    Key Record Dates
Last Update Posted: February 22, 2010
Last Verified: February 2010