This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Non-invasive Diagnosis of Coronary Artery Stenoses by Doppler Echocardiography

This study has been completed.
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: January 23, 2006
Last updated: July 15, 2016
Last verified: July 2016
Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.

Condition Intervention
Stable Angina Pectoris Unstable Angina Pectoris Acute Myocardial Infarction Procedure: Doppler echocardiography

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Non-invasive Evaluation of Coronary Pathology by Transthoracic Doppler Echocardiography. A Comparative Study to Coronary Angiography.

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Diagnostic yield: Accuracy, positive and negative predictive value. [ Time Frame: Inhospital ]
  • pr patient evaluation [ Time Frame: Inhospital ]

Secondary Outcome Measures:
  • pr stenosis evaluation [ Time Frame: Inhospital ]

Enrollment: 110
Study Start Date: December 2005
Study Completion Date: August 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: transthoracic Doppler echocardiography Procedure: Doppler echocardiography

Detailed Description:

Transthoracic Doppler echocardiographic evaluation with extensive evaluation of coronary stenoses in all 3 main branches using colour flow, pulsed Doppler and Coronary flow velocity reserve (CFVR)after pharmacologic stress with adenosin in the area of LAD and RDP. Blinded evaluation of Doppler results and coronary angiography regarding the other examination modality. Coronary angiography diagnostic "gold standard". Only stable and unstable patients otherwise scheduled for angiography on clinical reasons will be examined and included in the study.

Added January 2007 after ethics committee approval: comparison of CFVR with invasive fractional flow reserve (FFR) in selected subset of patients.


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • unstable angina or acute myocardial infarction, or stable angina pectoris and
  • scheduled for coronary angiography on accepted clinical reasons

Exclusion Criteria:

  • past coronary artery grafting
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00281346

Ålesund Hospital HF
Ålesund, Norway, N-6026
Sponsors and Collaborators
Norwegian University of Science and Technology
Study Chair: Torstein L Hole, MD, PhD Norwegian University of Science and Technology
Principal Investigator: Johnny Å Vegsundvåg, MD
Study Chair: Rune Wiseth, MD, PhD Norwegian University of Science and Technology
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Norwegian University of Science and Technology Identifier: NCT00281346     History of Changes
Other Study ID Numbers: 29 FU-71-05
Study First Received: January 23, 2006
Last Updated: July 15, 2016

Keywords provided by Norwegian University of Science and Technology:
Doppler echocardiography
coronary stenosis
Coronary angiography

Additional relevant MeSH terms:
Myocardial Infarction
Angina Pectoris
Angina, Stable
Angina, Unstable
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Chest Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on September 19, 2017