Innate and Adaptive Immunity in Individuals Experiencing Chronic Obstructive Pulmonary Disease Exacerbations
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The purpose of this study is to determine whether there is a statistical association between the changes from baseline in the levels of two cytokines interleukin (IL)-17A and IL-6 in the sputum of patients with chronic obstructive pulmonary disease (COPD) and the severity of acute exacerbations of COPD (AE-COPD). These sputum cytokine levels are taken as measures of the adaptive immune response (IL-17A) and the innate immune response (IL-6), respectively. Sputum will be collected either spontaneously or will be obtained by induction; cytokine levels will be measured by ELISA. The primary analysis, comparisons of sputum cytokine levels between clinical states, will be done using random effects modeling.
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Ages Eligible for Study:
40 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Recruited from pulmonary and general medicine clinics
Diagnosis of COPD (following American Thoracic Society guidelines) and/or chronic bronchitis
Forced Expiratory Volume in 1 second of less than 70% predicted value after bronchodilator
Current or former smokers with more than 20 pack-years
Daily productive cough for 3 months of the year for 2 consecutive years
At least one AE-COPD requiring medical attention in each year for the previous 3 years
Willingness to participate in follow-up studies defined in the protocol
Unstable cardiovascular disease
Other systemic disease in which survival of more than 2 years is unlikely
Mental incompetence or active psychiatric illness
Currently taking more than 20 mg/day of Prednisone
Participation in another experimental protocol within 6 weeks of study entry