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A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00280332
First Posted: January 23, 2006
Last Update Posted: May 12, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Chinese University of Hong Kong
  Purpose
  • To determine the prevalence of colonic neoplasm in patients who had previously undergone screening colonoscopy
  • To determine the optimal time interval for re-screening in average risk individuals
  • To determine potential baseline characteristics that predicts adenoma recurrence

Condition Intervention
Colonic Cancer Procedure: colonoscopy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy

Resource links provided by NLM:


Further study details as provided by Chinese University of Hong Kong:

Primary Outcome Measures:
  • The prevalence of advanced colonic adenoma in the re-screening population [ Time Frame: 5 year from index colonoscopy ]

Secondary Outcome Measures:
  • The time to adenoma adenoma development according to different baseline characteristics of patients and colonoscopy findings [ Time Frame: 5 years from index colonoscopy ]

Enrollment: 560
Study Start Date: March 2006
Study Completion Date: November 2007
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
A
colonic adenoma
Procedure: colonoscopy
proform a follow up colonoscopy in the 5 year period from index colonoscopy
Other Name: follow up colonoscopy
B
colonic without adenoma
Procedure: colonoscopy
proform a follow up colonoscopy in the 5 year period from index colonoscopy
Other Name: follow up colonoscopy

Detailed Description:

Colorectal cancer (CRC) is the second commonest cancer in Hong Kong, and tends to be increasing. Screening for colorectal cancer can reduce the cancer incidence and mortality by detecting early lesions. However, the best interval for a follow up colonoscopy, particularly for those with normal baseline colonoscopy, remains largely unknown.

This study aim to determine the prevalence of colonic neoplasm in average-risk patients who had previously undergone screening colonoscopy and the optimal time interval for re-screening.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects who are previously participated in one of our two screening colonoscopy studies [Sung, Gastroenterol 2003; Leung, AJG 2004]
Criteria

Inclusion Criteria:

  • Subjects who are previously participated in one of our two screening colonoscopy studies [Sung, Gastroenterol 2003; Leung, AJG 2004]
  • Asymptomatic on first screening colonoscopy
  • Age>50and <75
  • No family history of CRC
  • No other colonoscopy except the baseline screening colonoscopy

Exclusion Criteria:

  • Subjects who refused consent
  • Subjects who are not warrant follow up colonoscopy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00280332


Locations
China
Endoscopy Center, Prince of Wales Hospital
Hong Kong (SAR), China
Sponsors and Collaborators
Chinese University of Hong Kong
Investigators
Principal Investigator: Wai K Leung, MD CUHK
  More Information

Responsible Party: Dr WK Leung, Chinese University of Hong Kong
ClinicalTrials.gov Identifier: NCT00280332     History of Changes
Other Study ID Numbers: FUC
First Submitted: January 20, 2006
First Posted: January 23, 2006
Last Update Posted: May 12, 2008
Last Verified: May 2008

Keywords provided by Chinese University of Hong Kong:
colonic adenoma, colonic advanced neoplasm

Additional relevant MeSH terms:
Colonic Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases