Selenium and Immune Function
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|ClinicalTrials.gov Identifier: NCT00279812|
Recruitment Status : Completed
First Posted : January 20, 2006
Last Update Posted : March 21, 2011
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Behavioral: Selenomethionine (supplement) and selenium enriched onions||Not Applicable|
One of the proposed consequences of marginal selenium status is impaired immune function. Establishing the potential role of selenium as an enhancer of immune response in vivo may provide evidence-base for public health policy, with important consequences for preventing influenza and similar diseases in the elderly.
The project consists of a placebo controlled selenium supplementation study and a dietary intervention with un-enriched and selenium enriched onions. In a parallel group design, subjects will be given either one of three doses of Selenomethionine (50, 100 or 200µg selenium/day) or a placebo per day or selenium enriched or un-enriched onions (in the form of test meals) for 12 weeks. Changes in the expression of Se-responsive genes and proteins in blood will be measured and compared with changes in plasma Se concentration and selected selenoproteins. The relationship between dietary Se intake and systemic and mucosal immune responses to influenza vaccine will be examined. Changes in immune cell populations and the influence of Se on NK and CD8 cytotoxicity will be determined by flow cytometry.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||144 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Selenium and Immune Function|
|Study Start Date :||April 2005|
|Actual Study Completion Date :||August 2008|
- Cellular and humoral immune response
- Selenium status
- Selenoproteins and Se-biomarkers
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00279812
|Institute of Food Research|
|Norwich, Norfolk, United Kingdom, NR4 7UA|
|Principal Investigator:||Susan J Fairweather-Tait, BSc., MSc., PhD., DSc||University of East Anglia|